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Lookup NU author(s): Professor Martin Noble,
Professor Jane Endicott
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Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 strauroporine complex explains the tight binding of this inhibitor and suggests features to be exploited in the design of specific inhibitors of CDKs.
Author(s): Noble MEM; Endicott JA; Lawrie AM; Tunnah P; Brown NR; Johnson LN
Publication type: Letter
Publication status: Published
Journal: Nature Structural Biology
Print publication date: 01/10/1997
ISSN (print): 1072-8368
ISSN (electronic): 1545-9993
Publisher: NATURE PUBLISHING CO