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Clinical but not histological factors predict long-term prognosis in patients with histologically advanced non-decompensated alcoholic liver disease

Lookup NU author(s): Dr Steven MassonORCiD, Ingrid Emmerson, Elsbeth Henderson, Dr Emma Fletcher, Professor Alastair BurtORCiD, Professor Chris Day, Dr Stephen Stewart


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Background: Alcoholic liver disease (ALD) is a significant threat to public health and a leading cause of death. Despite this, the long-term clinical course and predictive factors of survival in histologically advanced ALD are not well described. Aims: The aim of this study was to identify clinical and histological factors that predict long-term (15-year) survival in outpatients with histologically advanced non-decompensated ALD. Methods: Patients (n=134) with biopsy-proven histologically advanced (stage III or IV) ALD were followed up for 15years or until death or orthotopic liver transplantation. At baseline, clinical and laboratory data were collected. On biopsy, the degree of fibrosis as well as other histological features (fat type and severity, lymphocyte and neutrophil infiltration) were scored semiquantitatively. Results: Most patients were male (72%) with a median age 51 (46-57). Overall, the 5-, 10- and 15-year survival was 63, 36 and 24% respectively. In multivariate analysis, persistent drinking (P=0.01), smoking (P=0.03), age (P=0.01) and serum albumin at baseline (P=0.001) were associated with significantly increased risk of death. Persistent drinking was associated with the highest risk. No histological features, including whether the stage of ALD was bridging fibrosis or cirrhosis, correlated with prognosis. Conclusion: In outpatients with biopsy-proven histologically advanced non-decompensated ALD, clinical but not histological factors determine prognosis. Persistent alcohol intake is the strongest predictor and smoking habit, age and serum albumin are also independently prognostic. Abstinence from alcohol and smoking cessation should be the priorities in the long-term management of ALD.

Publication metadata

Author(s): Masson S, Emmerson I, Henderson E, Fletcher EH, Burt AD, Day CP, Stewart SF

Publication type: Article

Publication status: Published

Journal: Liver International

Year: 2014

Volume: 34

Issue: 2

Pages: 235-242

Print publication date: 01/02/2014

Online publication date: 12/06/2013

Acceptance date: 04/06/2013

ISSN (print): 1478-3223

ISSN (electronic): 1478-3231

Publisher: Wiley-Blackwell


DOI: 10.1111/liv.12242


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