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Do the EULAR Sjögren’s syndrome outcome measures correlate with health status in primary Sjögren’s syndrome?

Lookup NU author(s): Dr Dennis LendremORCiD, Sheryl Mitchell, Dr Peter McMeekin, Dr Katie Hackett, Sarah Bowman, Dr David Coady, Dr Bridget Griffiths, Professor Fai NgORCiD


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Objective: This study investigates the relationship between health status (EQ-5D) in primary Sjögren’s syndrome and three of the EULAR Sjögren’s syndrome outcome measures – the disease activity index (ESSDAI), the patient reported index (ESSPRI) and the sicca score. Methods: Health status was evaluated using a standardised measure developed by the EuroQol Group - the EQ5D. This permits calculation of two measures of health status: time trade-off values (TTO) and the EQ5D visual analogue scale (VAS) scores. We used Spearman rank correlation analysis to investigate the strength of association between health status and three EULAR measures of physician and patient reported disease activity in 639 patients from the United Kingdom primary Sjögren’s syndrome registry (UKPSSR) cohort. Results: This study demonstrates that the EULAR Sjögren’s syndrome disease specific outcome measures are significantly correlated with health outcome values (p<0.001). Higher scores on the ESSDAI, EULAR sicca score and ESSPRI are associated with poorer health states – i.e. lower TTO values and lower VAS scores. While all three are significantly correlated with TTO values and EQ5D-VAS scores, the effect is strongest for the ESSPRI index. Conclusion: This study provides further evidence supporting the use of ESSDAI, EULAR sicca score and ESSPRI measures in the clinic. We also discuss the need for disease-specific measures of health status and their comparison to standardised health outcome measures. Normal 0 false false false EN-GB X-NONE X-NONE

Publication metadata

Author(s): Lendrem D, Mitchell S, McMeekin P, Gompels L, Hackett K, Bowman S, Price E, Pease CT, Emery P, Andrews J, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Vadivelu S, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, Ng W-F

Publication type: Article

Publication status: Published

Journal: Rheumatology

Year: 2015

Volume: 54

Issue: 4

Pages: 655-659

Print publication date: 01/04/2015

Online publication date: 19/09/2014

Acceptance date: 16/07/2014

ISSN (print): 1462-0324

ISSN (electronic): 1462-0332

Publisher: Oxford University Press


DOI: 10.1093/rheumatology/keu361

PubMed id: 25240612


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Funder referenceFunder name
G0800629Medical Research Council