Browse by author
Lookup NU author(s): Dr Naomi McGovern, Dr Merry Gunawan, Dr Laura JardineORCiD, Dr Elizabeth Poyner, Kile Green, Dr Rachel Dickinson, Dr Xiao WangORCiD, Katie Best, Dr Paul Milne, Sarah Pagan, Dr Venetia BigleyORCiD, Professor Matthew CollinORCiD, Professor Muzlifah Haniffa
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi) XCR1(+)CLEC9A(+) DCs and CD1c(+) DCs are murine CD103(+) DCs and CD64(-)CD11b(+) DCs. In addition, human tissues also contain CD14(+) cells, currently designated as DCs, with an as-yet unknown murine counterpart. Here we have demonstrated that human dermal CD14(+) cells are a tissue-resident population of monocyte-derived macrophages with a short half-life of <6 days. The decline and reconstitution kinetics of human blood CD14(+) monocytes and dermal CD14(+) cells in vivo supported their precursor-progeny relationship. The murine homologs of human dermal CD14(+) cells are CD11b(+) CD64(+) monocyte-derived macrophages. Human and mouse monocytes and macrophages were defined by highly conserved gene transcripts, which were distinct from DCs. The demonstration of monocyte-derived macrophages in the steady state in human tissue supports a conserved organization of human and mouse mononuclear phagocyte system.
Author(s): McGovern N, Schlitzer A, Gunawan M, Jardine L, Shin A, Poyner E, Green K, Dickinson R, Wang XN, Low D, Best K, Covins S, Milne P, Pagan S, Aljefri K, Windebank M, Saavedra DM, Larbi A, Wasan PS, Duan K, Poidinger M, Bigley V, Ginhoux F, Collin M, Haniffa M
Publication type: Article
Publication status: Published
Journal: Immunity
Year: 2014
Volume: 41
Issue: 3
Pages: 465-477
Print publication date: 18/09/2014
Online publication date: 04/09/2014
Acceptance date: 14/08/2014
Date deposited: 11/12/2014
ISSN (print): 1074-7613
ISSN (electronic): 1097-4180
Publisher: Cell Press
URL: http://dx.doi.org/10.1016/j.immuni.2014.08.006
DOI: 10.1016/j.immuni.2014.08.006
Altmetrics provided by Altmetric
