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Lookup NU author(s): Claire Schwab, Professor Christine Harrison FRCPath FMedSci
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MYC translocations represent a genetic subtype of T-lineage acute lymphoblastic leukemia (T-ALL), which occurs at an incidence of similar to 6%, assessed within a cohort of 196 T-ALL patients (64 adults and 132 children). The translocations were of 2 types; those rearranged with the T-cell receptor loci and those with other partners. MYC translocations were significantly associated with the TAL/LMO subtype of T-ALL (P=.018) and trisomies 6 (P < .001) and 7 (P < .001). Within the TAL/LMO subtype, gene expression profiling identified 148 differentially expressed genes between patients with and without MYC translocations; specifically, 77 were upregulated and 71 downregulated in those with MYC translocations. The poor prognostic marker, CD44, was among the upregulated genes. MYC translocations occurred as secondary abnormalities, present in subclones in one-half of the cases. Longitudinal studies indicated an association with induction failure and relapse.
Author(s): La Starza R, Borga C, Barba G, Pierini V, Schwab C, Matteucci C, Fernandez AGL, Leszl A, Cazzaniga G, Chiaretti S, Basso G, Harrison CJ, te Kronnie G, Mecucci C
Publication type: Article
Publication status: Published
Journal: Blood
Year: 2014
Volume: 124
Issue: 24
Pages: 3577-3582
Print publication date: 04/12/2014
Online publication date: 30/09/2014
Acceptance date: 12/09/2014
ISSN (print): 0006-4971
ISSN (electronic): 1528-0020
Publisher: American Society of Hematology
DOI: 10.1182/blood-2014-06-578856
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