Publications by Claire Schwab - ePrints

Browsing publications by Claire Schwab.

Newcastle Authors	Title	Year
Claire Schwab Emerita Professor Christine Harrison	Paediatric bone marrow mesenchymal stem cells support acute myeloid leukaemia cell survival and enhance chemoresistance via contact-independent mechanism	2025
Dr Dino Masic Kayleigh Fee Dr Hayden Bell Marian Case Juan Ojeda Garcia et al.	Hyperactive CREB subpopulations increase during therapy in pediatric B-lineage acute lymphoblastic leukemia	2023
Claire Schwab Dr Ruth Cranston Dr Sarra Ryan Ellie Butler Emily Winterman et al.	Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial	2023
Sarra Ryan Dr Ruth Cranston Claire Schwab Dr Matthew Bashton Dr Paul Sinclair et al.	The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21	2023
Sarra Ryan Claire Schwab Dr Richard Yim Dr Ruth Cranston Dr Lisa Russell et al.	Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia	2023
Claire Schwab Daniel Murdy Ellie Butler Dr Amir Enshaei Emily Winterman et al.	Genetic characterisation of childhood B-other-acute lymphoblastic leukaemia in UK patients by fluorescence in situ hybridisation and Multiplex Ligation-dependent Probe Amplification	2022
Dr Deepali Pal Dr Helen Blair Sean Hockney Dr Melanie Beckett Mankaran Singh et al.	hiPSC-derived bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukemia	2022
Professor Anthony Moorman Emilio Barretta Ellie Butler Eleanor Ward Dr Amir Enshaei et al.	Prognostic impact of chromosomal abnormalities and copy number alterations in adult B-cell precursor acute lymphoblastic leukaemia: a UKALL14 study	2022
Claire Schwab Professor Anthony Moorman	SSBP2-CSF1R is a recurrent fusion in B-lineage acute lymphoblastic leukemia with diverse genetic presentation and variable outcome	2021
Claire Schwab Professor Christine Harrison FRCPath FMedSci	Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study	2021
Claire Schwab	MYB rearrangements and over-expression in T-cell acute lymphoblastic leukemia	2021
Dr Tom Creasey Dr Amir Enshaei Claire Schwab Kathryn Watts Gavin Cuthbert et al.	Single nucleotide polymorphism (SNP) array-based signature of low hypodiploidy in acute lymphoblastic leukemia	2021
Dr Amir Enshaei Professor Christine Harrison FRCPath FMedSci Claire Schwab Professor Anthony Moorman	A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia	2020
Professor Anthony Moorman Claire Schwab Emily Winterman Dr Frederik van Delft Professor Christine Harrison FRCPath FMedSci et al.	Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion	2020
Dr Matthew Bashton Robin Hollis Dr Sarra Ryan Claire Schwab Professor Christine Harrison FRCPath FMedSci et al.	Concordance of copy number abnormality detection using SNP arrays and Multiplex Ligation-dependent Probe Amplification (MLPA) in acute lymphoblastic leukaemia	2020
Claire Schwab Professor Christine Harrison FRCPath FMedSci	Design of a Comprehensive Fluorescence in Situ Hybridization Assay for Genetic Classification of T-Cell Acute Lymphoblastic Leukemia	2020
Claire Schwab Professor Christine Harrison FRCPath FMedSci	Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia	2019
Dr Paul Sinclair Dr Sarra Ryan Dr Matthew Bashton Shaun Hollern Rebecca Hanna et al.	SH2B3 inactivation through CN-LOH-12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain	2019
Dr Tom Creasey Dr Amir Enshaei Kathryn Watts Gavin Cuthbert Claire Schwab et al.	Single Nucleotide Polymorphism Array-Based Signature of Genetic Ploidy Groups in Acute Lymphoblastic Leukemia	2019
Dr Lina Hamadeh Dr Amir Enshaei Claire Schwab Professor Christine Harrison FRCPath FMedSci Professor Anthony Moorman et al.	Validation of the United Kingdom copy-number alteration classifier in 3239 children with B-cell precursor ALL	2019
Dr Paul Sinclair Dr Helen Blair Dr Sarra Ryan Dr Lars Buechler Joanna Cheng et al.	Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21	2018
Claire Schwab Professor Christine Harrison FRCPath FMedSci	The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling	2018
Dr Britta Vormoor Professor Gareth Veal Melanie Griffin Professor Julie Irving Lynne Minto et al.	A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia	2017
Claire Schwab Professor Christine Harrison FRCPath FMedSci	Digital Multiplex Ligation-Dependent Probe Amplification for Detection of Key Copy Number Alterations in T- and B-Cell Lymphoblastic Leukemia	2017
Dr Amir Enshaei Professor Christine Harrison FRCPath FMedSci Dr Sujith Samarasinghe Claire Schwab Professor Anthony Moorman et al.	Genotype-Specific Minimal Residual Disease Interpretation Improves Stratification in Pediatric Acute Lymphoblastic Leukemia	2017
Claire Schwab Dr Lucy Chilton Professor Anthony Moorman Professor Christine Harrison FRCPath FMedSci	Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?	2017
Professor Anthony Moorman Claire Schwab Professor Christine Harrison FRCPath FMedSci Dr Sujith Samarasinghe	Use of minimal residual disease assessment to redefine induction failure in pediatric acute lymphoblastic leukemia	2017
Claire Schwab Sarra Ryan Dr Lucy Chilton Alannah Elliott James Murray et al.	EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL): genetic profile and clinical implications	2016
Professor Anthony Moorman Claire Schwab	Characterization of leukemias with ETV6-ABL1 fusion	2016
Professor Christine Harrison FRCPath FMedSci Claire Schwab	Constitutional abnormalities of chromosome 21 predispose to iAMP21-acute lymphoblastic leukaemia	2016
Claire Schwab Professor Christine Harrison FRCPath FMedSci	Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia	2016
Claire Schwab Professor Christine Harrison FRCPath FMedSci	Genetic characterization and therapeutic targeting of MYC translocated pediatric T-cell acute lymphoblastic leukemia	2016
Professor Julie Irving Dr Amir Enshaei Dr Amy Erhorn Lynne Minto Claire Schwab et al.	Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukaemia	2016
Claire Schwab Dr Amir Enshaei Dr Lisa Russell Professor Anthony Moorman	The Frequency and Outcome of Ph-like ALL Associated Abnormalities in Childhood Acute Lymphoblastic Leukaemia Treated on MRC UKALL2003	2016
Dr Sarra Ryan Elizabeth Matheson Dr Paul Sinclair Dr Matthew Bashton Claire Schwab et al.	The role of the RAS pathway in iAMP21-ALL	2016
Dr Al Gabriel Dr Amir Enshaei Jennifer Taylor Dr Amy Erhorn Claire Schwab et al.	Age specific incidence of partner gene and secondary abnormalities in MLL positive acute lymphoblastic leukaemia (ALL)	2015
Professor Anthony Moorman Claire Schwab Karen Marshall	Characterization of Leukemias with ETV6-ABL1 Fusion	2015
Professor Anthony Moorman Professor Julie Irving Dr Amir Enshaei Dr Amy Erhorn Lynne Minto et al.	Composite Index for Risk Prediction in Relapsed Childhood Acute Lymphoblastic Leukaemia	2015
Dr Al Gabriel Fadhel Alsaid Naji Dr Ed Schwalbe Dr Sirintra Nakjang Dr Simon Cockell et al.	Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia	2015
Claire Schwab Dr Amir Enshaei Professor Anthony Moorman	Prognostic value of rare IKZF1 deletion in childhood b-cell precursor acute lymphoblastic leukemia: an international collaborative study	2015
Dr Lindsay Nicholson Elizabeth Matheson Lynne Minto Christopher Keilty Maryna Sanichar et al.	Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition	2015
Dr Amir Enshaei Claire Schwab Dr Lucy Chilton Professor Anthony Moorman	Risk Factor Analysis in Paediatric Acute Lymphoblastic Leukaemia with High Hyperdiploidy	2015
Dr Amir Enshaei Claire Schwab Dr Lucy Chilton Professor Christine Harrison FRCPath FMedSci Professor Anthony Moorman et al.	Risk Factor Analysis in Paediatric Acute Lymphoblastic Leukaemia with High Hyperdiploidy	2015
Claire Schwab Alannah Elliott Dr Lucy Chilton Professor Anthony Moorman Professor Christine Harrison FRCPath FMedSci et al.	Targeted Sequencing Identifies Association Between IL7R-JAK Mutations And Epigenetic Modulators In T-Cell Acute Lymphoblastic Leukemia.	2015
Claire Schwab Professor Christine Harrison FRCPath FMedSci	ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling	2015
Claire Schwab Dr Amir Enshaei Professor Anthony Moorman	368 Prognostic Value of Rare IKZF1 deletions in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia: An International Collaborative Study	2014
Professor Anthony Moorman Dr Amir Enshaei Claire Schwab Dr Lucy Chilton Alannah Elliott et al.	A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia	2014
Claire Schwab Professor Christine Harrison FRCPath FMedSci	CMYC-translocations in t-cell acute lymphoblastic leukemia	2014
Claire Schwab Sarra Ryan Professor Anthony Moorman Dr Richard McNally Professor Bryan Young et al.	Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia	2014
Claire Schwab Dr Sarra Ryan Professor Christine Harrison FRCPath FMedSci	Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia	2014
Claire Schwab Becca Andrews Dr Lucy Chilton Alannah Elliott Gerald Keil et al.	EBF1-PDGFRB Fusion in Paediatric Acute Lymphoblastic Leukaemia (ALL): Genetic Profile and Clinical Implications	2014
Claire Schwab Professor Christine Harrison FRCPath FMedSci	Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations	2014
Claire Schwab Professor Anthony Moorman	Mouse xenograft modeling of human adult acute lymphoblastic leukemia provides mechanistic insights into adult LIC biology	2014
Claire Schwab Dr Amir Enshaei Professor Anthony Moorman	Prognostic Value of Rare IKZF1 deletions in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia: An International Collaborative Study	2014
Professor Christine Harrison FRCPath FMedSci Claire Schwab	Refinement of IKZF1 Genomic Status in Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia	2014
Claire Schwab Becca Andrews Dr Lucy Chilton Alannah Elliott Dr Stacey Richardson et al.	SSBP2-CSF1R Is a Recurrent Fusion in B-Other Acute Lymphoblastic Leukaemia with Variable Clinical Outcome	2014
Claire Schwab Professor Christine Harrison FRCPath FMedSci Professor Anthony Moorman	BTG1 deletions do not predict outcome in Down syndrome acute lymphoblastic leukemia	2013
Dr Halima Al-shehhi Claire Schwab Dr Amy Erhorn Dr Al Gabriel Professor Christine Harrison FRCPath FMedSci et al.	Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia	2013
Professor Christine Harrison FRCPath FMedSci Professor Anthony Moorman Claire Schwab Dr Lucy Chilton	An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome	2013
Claire Schwab Dr Lucy Chilton Heather Morrison Lisa Jones Dr Halima Al-shehhi et al.	Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features	2013
Professor Anthony Moorman Dr Amir Enshaei Claire Schwab Dr Lucy Chilton	Integration Of Cytogenetic and Copy Number Alteration (CNA) Data Into a Single Risk Profile For Paediatric Acute Lymphoblastic Leukaemia (ALL)	2013
Dr Amir Enshaei Claire Schwab Professor Christine Harrison FRCPath FMedSci Professor Anthony Moorman	Long-term follow-up of ETV6-RUNX1 ALL reveals that NCI risk, rather than secondary genetic abnormalities, is the key risk factor	2013
Professor Anthony Moorman Claire Schwab Professor Christine Harrison FRCPath FMedSci	Risk-Directed Treatment Intensification Significantly Reduces the Risk of Relapse Among Children and Adolescents With Acute Lymphoblastic Leukemia and Intrachromosomal Amplification of Chromosome 21: A Comparison of the MRC ALL97/99 and UKALL2003 Trials	2013
Dr Emma Fairhall Dr Michelle Charles Karen Wallace Claire Schwab Professor Christine Harrison FRCPath FMedSci et al.	The B-13 hepatocyte progenitor cell resists pluripotency induction and differentiation to non-hepatocyte cells.	2013
Dr Emma Fairhall Claire Schwab Professor Christine Harrison FRCPath FMedSci Dr Karen Wallace Professor Matthew Wright et al.	The Hepatic Progenitor B-13 Cell Line Engrafts into the Mouse Liver and Transdifferentiates in Vivo	2013
Dr Peter Carey Claire Schwab Dr Lucy Chilton Dr Ed Schwalbe Professor Roderick Skinner et al.	Treating childhood acute lymphoblastic leukemia in Malawi	2013
Professor Anthony Moorman Claire Schwab Hannah Ensor Dr Lisa Russell Heather Morrison et al.	IGH@ Translocations, CRLF2 Deregulation and Microdeletions in Adolescents and Adults with Acute Lymphoblastic Leukemia	2012
Claire Schwab Dr Lucy Chilton Dr Amir Enshaei Heather Morrison Lisa Jones et al.	Clinical Relevance of Genes Commonly Deleted in Childhood B-Cell Precursor ALL (BCP-ALL)	2012
Professor Anthony Moorman Dr Amir Enshaei Dr Lucy Chilton Claire Schwab Professor Christine Harrison FRCPath FMedSci et al.	Delineation of Risk Factors in Paediatric Acute Lymphoblastic Leukaemia with Favourable Cytogenetics	2012
Claire Schwab Professor Anthony Moorman Professor Christine Harrison FRCPath FMedSci	Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia	2012
Claire Schwab Dr Lucy Chilton Heather Morrison Lisa Jones Dr Halima Al-shehhi et al.	Genes Commonly Deleted in Childhood B-Cell Precursor ALL (BCP-ALL) Are Associated with Major Cytogenetic Subgroups	2012
Professor Christine Harrison FRCPath FMedSci Professor Anthony Moorman Claire Schwab	Intrachromosomal Amplification of Chromosome 21(iAMP21): Cytogenetic Characterisation and Outcome in Childhood B-Cell Precursor Acute Lymphoblastic Leukaemia (BCP-ALL). A Study On Behalf of the Ponte Di Legno International Childhood ALL Workshop	2012
Dr Lisa Russell Claire Schwab Professor Christine Harrison FRCPath FMedSci Professor Anthony Moorman	Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations	2012
Hannah Ensor Claire Schwab Dr Lisa Russell Professor Christine Harrison FRCPath FMedSci Professor Anthony Moorman et al.	Treatment outcome of CRLF2-rearranged childhood acute lymphoblastic leukaemia: a comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups	2012
Hannah Ensor Claire Schwab Dr Lisa Russell Heather Morrison Dr Dino Masic et al.	Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial	2011
Dr Vikki Rand Dr Lisa Russell Claire Schwab Hannah Ensor Professor Julie Irving et al.	Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia	2011
Dr Lindsay Nicholson Charlotte Evans Elizabeth Matheson Lynne Minto Christopher Keilty et al.	Quantitative Proteomic Analysis Reveals Maturation As a Mechanism Underlying Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia and PAX5 As a Re-Sensitising Therapeutic Target	2011
Dr Sarra Ryan Dr Vikki Rand Claire Schwab Heather Morrison Elizabeth Matheson et al.	Ras Signalling Pathway and Novel Target Genes Related to Down Syndrome Contribute to the Development of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in iAMP21 Patients	2011
Claire Schwab Lisa Jones Heather Morrison Dr Sarra Ryan Professor Christine Harrison FRCPath FMedSci et al.	Evaluation of Multiplex Ligation-Dependent Probe Amplification as a Method for the Detection of Copy Number Abnormalities in B-Cell Precursor Acute Lymphoblastic Leukemia	2010
Professor Christine Harrison FRCPath FMedSci Claire Schwab	PHF6 mutations in T-cell acute lymphoblastic leukemia	2010
Professor Anthony Moorman Hannah Ensor Dr Lucy Chilton Claire Schwab Professor Christine Harrison FRCPath FMedSci et al.	Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial	2010
Dr Lisa Russell Professor Olaf Heidenreich Professor Julie Irving Professor Anthony Moorman Heather Morrison et al.	Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia	2009
Dr Vikki Rand Dr Lisa Russell Professor Julie Irving Lisa Jones Dr Dino Masic et al.	What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?	2009
Dr Carol English Claire Schwab	Multiple structurally abnormal cell lines involving the same chromosome breakpoint: two cases detected by chorion villus biopsy	2002