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Aberrations in DNA methylation are detectable during remission of acute lymphoblastic leukemia and predict patient outcome

Lookup NU author(s): Sanne van Otterdijk, Jean Norden, Professor Anne Dickinson, Professor Mark PearceORCiD, Professor Caroline Relton, Professor John Mathers, Dr Gordon Strathdee


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Aim: Aberrant DNA methylation patterns are a hallmark of cancer, although the extent to which they underlie cancer development is unknown. In this study, we aimed to determine whether acute lymphoblastic leukemia (ALL) patients in clinical remission retained abnormal DNA methylation patters and whether these were associated with patient outcome. Materials & methods: We investigated CpG island methylation of genes known to exhibit hypermethylation in leukemia using quantitative pyrosequencing analysis. Results: Although methylation levels were reduced in remission samples, they remained significantly higher than those seen in healthy controls. This retained methylation was not related to low levels of residual leukemia cells still present at remission. Methylation levels were also stable (or increased) during continuous remission and significantly correlated with long-term survival in adult ALL patients. Conclusion: This study determined that abnormalities in DNA methylation are retained during ALL remission and may represent a novel prognostic marker for adult ALL patients.

Publication metadata

Author(s): van Otterdijk SD, Norden J, Dickinson AM, Pearce MS, Relton CL, Mathers JC, Strathdee G

Publication type: Article

Publication status: Published

Journal: Epigenomics

Year: 2015

Volume: 7

Issue: 1

Pages: 35-45

Print publication date: 01/01/2015

ISSN (print): 1750-1911

ISSN (electronic): 1750-192X

Publisher: Future Medicine Ltd.


DOI: 10.2217/EPI.14.78


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