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Genetics of Alcoholic Liver Disease

Lookup NU author(s): Professor Quentin AnsteeORCiD, Professor Ann DalyORCiD, Professor Chris Day


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Excess alcohol consumption with consequent alcoholic liver disease (ALD) is a common cause of liver dysfunction and liver-related mortality worldwide. However, although the majority of heavy drinkers will develop steatosis, only a minority progress to advanced liver disease and cirrhosis. Thus, ALD is a complex disease where subtle interpatient genetic variations and environmental factors interact to determine disease progression. One genome-wide association study specifically addressing geneticmodifiers of ALD has been published. However, most of our understanding is based on studies conducted on nonalcoholic fatty liver disease. Translation of candidates from these studies into ALD has established a role for variants in genes including PNPLA3 and potentially TM6SF2 across the disease spectrum from steatosis, through cirrhosis to hepatocellular carcinoma. Here the authors review the current status of the field with a particular focus on recent advances.

Publication metadata

Author(s): Anstee QM, Daly AK, Day CP

Publication type: Review

Publication status: Published

Journal: Seminars in Liver Disease

Year: 2015

Volume: 35

Issue: 4

Pages: 361-374

Print publication date: 01/11/2015

Acceptance date: 01/01/1900

ISSN (print): 0272-8087

ISSN (electronic): 1098-8971



DOI: 10.1055/s-0035-1567832