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Predicting fatty acid profiles in blood based on food intake and the FADS1 rs174546 SNP

Lookup NU author(s): Dr Carlos Celis Morales, Professor John Mathers, Eileen Gibney, Professor Lorraine Brennan

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Abstract

Scope: A high intake of n-3 PUFA provides health benefits via changes in the n-6/n-3 ratio in blood. In addition to such dietary PUFAs, variants in the fatty acid desaturase 1 (FADS1) gene are also associated with altered PUFA profiles.Methods and results: We used mathematical modeling to predict levels of PUFA in whole blood, based on multiple hypothesis testing and bootstrapped LASSO selected food items, anthropometric and lifestyle factors, and the rs174546 genotypes in FADS1 from 1607 participants (Food4Me Study). The models were developed using data from the first reported time point (training set) and their predictive power was evaluated using data from the last reported time point (test set). Among other food items, fish, pizza, chicken, and cereals were identified as being associated with the PUFA profiles. Using these food items and the rs174546 genotypes as predictors, models explained 26-43% of the variability in PUFA concentrations in the training set and 22-33% in the test set.Conclusion: Selecting food items using multiple hypothesis testing is a valuable contribution to determine predictors, as our models' predictive power is higher compared to analogue studies. As unique feature, we additionally confirmed our models' power based on a test set.

Publication metadata

Author(s): Hallmann J, Kolossa S, Gedrich K, Celis-Morales C, Forster H, O'Donovan CB, Woolhead C, Macready AL, Fallaize R, Marsaux CFM, Lambrinou CP, Mavrogianni C, Moschonis G, Navas-Carretero S, San-Cristobal R, Godlewska M, Surwillo A, Mathers JC, Gibney ER, Brennan L, Walsh MC, Lovegrove JA, Saris WHM, Manios Y, Martinez JA, Traczyk I, Gibney MJ, Daniel H, Food4Me Study

Publication type: Article

Publication status: Published

Journal: Molecular Nutrition & Food Research

Year: 2015

Volume: 59

Issue: 12

Pages: 2565-2573

Print publication date: 01/12/2015

Online publication date: 30/09/2015

Acceptance date: 20/08/2015

ISSN (print): 1613-4125

ISSN (electronic): 1613-4133

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1002/mnfr.201500414

DOI: 10.1002/mnfr.201500414

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