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Lookup NU author(s): Dr Katherine Livingstone, Dr Carlos Celis Morales, Professor Lorraine Brennan, Professor John Mathers
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The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AAv. TT: +14 cm; P=0003) and BMI (+09 kg/m(2); P=0001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 14 kg/m(2) greater BMI (P-trend=0028) and 31 cm greater WC (P-trend=0045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.
Author(s): Livingstone KM, Celis-Morales C, Navas-Carretero S, San-Cristobal R, Forster H, O'Donovan CB, Woolhead C, Marsaux CFM, Macready AL, Fallaize R, Kolossa S, Tsirigoti L, Lambrinou CP, Moschonis G, Godlewska M, Surwillo A, Drevon CA, Manios Y, Traczyk I, Gibney ER, Brennan L, Walsh MC, Lovegrove JA, Martinez JA, Saris WHM, Daniel H, Gibney M, Mathers JC, Food4Me Study
Publication type: Article
Publication status: Published
Journal: British Journal of Nutrition
Year: 2016
Volume: 115
Issue: 3
Pages: 440-448
Print publication date: 01/02/2016
Online publication date: 01/12/2015
Acceptance date: 28/10/2015
ISSN (print): 0007-1145
ISSN (electronic): 1475-2662
Publisher: Cambridge University Press
URL: http://dx.doi.org/10.1017/S0007114515004675
DOI: 10.1017/S0007114515004675
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