Toggle Main Menu Toggle Search

Open Access padlockePrints

Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study

Lookup NU author(s): Dr Carlos Celis Morales, Dr Katherine Livingstone, Professor Lorraine Brennan, Professor John Mathers


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


ObjectiveTo examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults.MethodsOf 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet.ResultsFTO genotype was associated with a higher body weight [: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P=0.024], BMI [: 0.54 kgm(-2), (0.23-0.83), P<0.0001], and WC [: 1.07 cm, (0.24-1.90), P=0.011]. Moderate-equivalent PA attenuated the effect of FTO on BMI (P-[interaction]=0.020). Among inactive individuals, FTO increased BMI by 1.06 kgm(-2) per allele (P=0.024), whereas the increase in BMI was substantially attenuated among active individuals (0.16 kgm(-2), P=0.388). We observed similar effects for WC (P-[interaction]=0.005): the FTO risk allele increased WC by 2.72 cm per allele among inactive individuals but by only 0.49 cm in active individuals.ConclusionsPA attenuates the effect of FTO genotype on BMI and WC. This may have important public health implications because genetic susceptibility to obesity in the presence of FTO variants may be reduced by adopting a physically active lifestyle.

Publication metadata

Author(s): Celis-Morales C, Marsaux CFM, Livingstone KM, Navas-Carretero S, San-Cristobal R, O'donovan CB, Forster H, Woolhead C, Fallaize R, Macready AL, Kolossa S, Hallmann J, Tsirigoti L, Lambrinou CP, Moschonis G, Godlewska M, Surwillo A, Grimaldi K, Bouwman J, Manios Y, Traczyk I, Drevon CA, Parnell LD, Daniel H, Gibney ER, Brennan L, Walsh MC, Gibney M, Lovegrove JA, Martinez JA, Saris WHM, Mathers JC, Food4Me Study

Publication type: Article

Publication status: Published

Journal: Obesity

Year: 2016

Volume: 24

Issue: 4

Pages: 962-969

Print publication date: 01/04/2016

Online publication date: 27/02/2016

Acceptance date: 19/11/2015

ISSN (print): 1930-7381

ISSN (electronic): 1930-739X

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1002/oby.21422


Altmetrics provided by Altmetric


Funder referenceFunder name
265494European Commission