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Lookup NU author(s): Dr Carlos Celis Morales,
Dr Katherine Livingstone,
Professor Lorraine Brennan,
Professor John Mathers
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ObjectiveTo examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults.MethodsOf 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet.ResultsFTO genotype was associated with a higher body weight [: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P=0.024], BMI [: 0.54 kgm(-2), (0.23-0.83), P<0.0001], and WC [: 1.07 cm, (0.24-1.90), P=0.011]. Moderate-equivalent PA attenuated the effect of FTO on BMI (P-[interaction]=0.020). Among inactive individuals, FTO increased BMI by 1.06 kgm(-2) per allele (P=0.024), whereas the increase in BMI was substantially attenuated among active individuals (0.16 kgm(-2), P=0.388). We observed similar effects for WC (P-[interaction]=0.005): the FTO risk allele increased WC by 2.72 cm per allele among inactive individuals but by only 0.49 cm in active individuals.ConclusionsPA attenuates the effect of FTO genotype on BMI and WC. This may have important public health implications because genetic susceptibility to obesity in the presence of FTO variants may be reduced by adopting a physically active lifestyle.
Author(s): Celis-Morales C, Marsaux CFM, Livingstone KM, Navas-Carretero S, San-Cristobal R, O'donovan CB, Forster H, Woolhead C, Fallaize R, Macready AL, Kolossa S, Hallmann J, Tsirigoti L, Lambrinou CP, Moschonis G, Godlewska M, Surwillo A, Grimaldi K, Bouwman J, Manios Y, Traczyk I, Drevon CA, Parnell LD, Daniel H, Gibney ER, Brennan L, Walsh MC, Gibney M, Lovegrove JA, Martinez JA, Saris WHM, Mathers JC, Food4Me Study
Publication type: Article
Publication status: Published
Print publication date: 01/04/2016
Online publication date: 27/02/2016
Acceptance date: 19/11/2015
ISSN (print): 1930-7381
ISSN (electronic): 1930-739X
Publisher: Wiley-Blackwell Publishing Ltd.
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