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Osteopontin and HMGB1: novel regulators of HSC activation

Lookup NU author(s): Dr Lee Borthwick, Professor Derek Mann



Liver fibrosis, the accumulation of extracellular matrix proteins caused by chronic liver damage, results from the activation of hepatic stellate cells. In a new study, Arriazu et al. explore in detail the mechanisms by which the multifunctional protein osteopontin drives hepatic fibrosis, and show that interaction with HMGB1 mediates the fibrogenic response.

Publication metadata

Author(s): Borthwick LA, Mann DA

Publication type: Editorial

Publication status: Published

Journal: Nature Reviews Gastroenterology & Hepatology

Year: 2016

Volume: 13

Issue: 6

Pages: 320-322

Print publication date: 01/06/2016

Online publication date: 14/04/2016

Acceptance date: 01/01/1900

ISSN (print): 1759-5045

ISSN (electronic): 1759-5053

Publisher: Nature Publishing Group


DOI: 10.1038/nrgastro.2016.58