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Lookup NU author(s): Dr Pamela Gamba,
Dr Katherine James,
Professor Nikolay Zenkin
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2017 The Author(s). Published with license by Taylor & Francis © 2017, © Pamela Gamba, Katherine James, and Nikolay Zenkin. Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.
Author(s): Gamba P, James K, Zenkin N
Publication type: Review
Publication status: Published
Online publication date: 10/01/2017
Acceptance date: 12/12/2016
ISSN (print): 2154-1264
ISSN (electronic): 2154-1272
Publisher: Taylor and Francis Inc.