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A link between transcription fidelity and pausing in vivo

Lookup NU author(s): Dr Pamela Gamba, Dr Katherine JamesORCiD, Professor Nikolay ZenkinORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2017 The Author(s). Published with license by Taylor & Francis © 2017, © Pamela Gamba, Katherine James, and Nikolay Zenkin. Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.

Publication metadata

Author(s): Gamba P, James K, Zenkin N

Publication type: Review

Publication status: Published

Journal: Transcription

Year: 2017

Volume: 8

Issue: 2

Pages: 99-105

Online publication date: 10/01/2017

Acceptance date: 12/12/2016

ISSN (print): 2154-1264

ISSN (electronic): 2154-1272

Publisher: Taylor and Francis Inc.


DOI: 10.1080/21541264.2016.1274812