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Preparation of isoindolinones as inhibitors of the MDM2-​p53 interaction having anticancer activity;WO 2017055860

Lookup NU author(s): Professor David Rees, Emeritus Professor Bernard Golding, Dr Ian HardcastleORCiD, Dr Celine CanoORCiD, Duncan MillerORCiD, Professor Martin NobleORCiD, Professor Roger Griffin


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The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Publication metadata

Inventor(s): Chessari G, Howard S, Buck IM, Cons BD, Johnson CN, Holvey RS, Rees DC, StDenis JD, Tamanini E, Golding BT, Hardcastle IR, Cano CF, Miller DC, Noble MEM, Osborne JD, Peach J, Lewis A, Hirst KL, Whittaker BP, Watson DW, Mitchell DR, Griffin RJ

Publication type: Patent

Publication status: Published

Year: 2017

Online publication date: 06/04/2017

Acceptance date: 29/09/2016