Publications by Duncan Miller - ePrints

Browsing publications by Duncan Miller.

Newcastle Authors	Title	Year
Dr Elaine Willmore Suzanne Kyle Dr Yan Zhao Huw Thomas Dr Kenneth Rankin et al.	Targeting the MDM2-p53 interaction: Time- and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic index	2024
Duncan Miller Dr Suzannah Harnor Dr Mathew Martin Dr Richard Noble Professor Steve Wedge et al.	Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy	2023
Duncan Miller Tristan Reuillon Dr Lauren Molyneux Dr Tim Blackburn Dr Noel Edwards et al.	Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor	2022
Islam Al-Khawaldeh Dr Christine Basmadjian Dr Cinzia Bordoni Dr Suzannah Harnor Amy Heptinstall et al.	An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)	2021
Dr Cinzia Bordoni Daniel Brough Gemma Davison James Hunter Daniel Lopez Fernandez et al.	Cardiac Ion Channel Inhibition	2021
Dr Ian Hardcastle Dr Ruth Bawn Dr Tim Blackburn Dr Celine Cano Dr Sarah Cully et al.	Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction	2021
Daniel Wood Daniel Lopez Fernandez Leanne Knight Islam Al-Khawaldeh Dr Conghao Gai et al.	FragLites - minimal, halogenated fragments displaying pharmacophore doublets. An efficient approach to druggability assessment and hit generation	2019
Stephanie Myers Duncan Miller Dr Lauren Molyneux Dr Mercedeh Arasta Dr Ruth Bawn et al.	Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4	2019
Duncan Miller	The discovery and optimization of benzimidazoles as selective Na_V1.8 blockers for the treatment of pain	2019
Duncan Miller Dr Mathew Martin Santosh Adhikari Alfie Brennan Professor Jane Endicott et al.	Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach	2018
Professor David Rees Emeritus Professor Bernard Golding Dr Ian Hardcastle Dr Celine Cano Duncan Miller et al.	ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY	2017
Professor David Rees Emeritus Professor Bernard Golding Dr Ian Hardcastle Dr Celine Cano Duncan Miller et al.	Preparation of isoindolinones as inhibitors of the MDM2-p53 interaction having anticancer activity	2017
Professor David Rees Emeritus Professor Bernard Golding Dr Ian Hardcastle Dr Celine Cano Duncan Miller et al.	Preparation of isoindolinones as inhibitors of the MDM2-p53 interaction having anticancer activity;WO 2017055860	2017
Tristan Reuillon Dr Sari Alhasan Dr Gary Beale Annalisa Bertoli Alfie Brennan et al.	Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases	2016
Duncan Miller	Discovery and optimisation of potent and highly subtype selective Na_v1.8 inhibitors with reduced cardiovascular liabilities	2016
Tristan Reuillon Duncan Miller Stephanie Myers Dr Lauren Molyneux Dr Celine Cano et al.	Pyrrolcarboxamide Derivatives for the Inhibition of ERK5	2016
Professor Mike Waring Duncan Miller	Challenges in the Medicinal Chemical Optimization of Binding Kinetics	2015
Duncan Miller Dr Benoit Carbain Dr Gary Beale Dr Sari Alhasan Professor Helen Reeves et al.	Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases	2015
Andrew Shouksmith Laura Evans Professor Deborah Tweddle Duncan Miller Dr Elaine Willmore et al.	Synthesis and Activity of Putative Small-Molecule Inhibitors of the F-Box Protein SKP2	2015
Andrew Shouksmith Laura Evans Professor Roger Griffin Emeritus Professor Bernard Golding Professor Herbie Newell et al.	Design and synthesis of putative small-molecule inhibitors targeting the SCFSKP2 E3 ligase complex	2014
Duncan Miller	Benzimidazole and imidazopyridine derivatives as Nav1.8 inhibitors and their preparation and use in the treatment of pain	2013
Duncan Miller	Imidazoles as Nav1.8 inhibitors and their preparation and use in the treatment of pain	2013
Tristan Reuillon Annalisa Bertoli Professor Roger Griffin Duncan Miller Emeritus Professor Bernard Golding et al.	Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groups	2012
Duncan Miller Dr Peter Jones	Investigation of the effect of molecular properties on the binding kinetics of a ligand to its biological target	2012