Browse by author
Lookup NU author(s): Zak Gamie, Dr Emma Haagensen, Ricardo da Conceicao Ribeiro, Professor Kenneth Dalgarno, Dr Anja Krippner-Heidenreich, Craig Gerrand, Dr Kenneth RankinORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2017 Elsevier B.V. Bone sarcomas are rare, highly malignant mesenchymal tumours that affect teenagers and young adults, as well as older patients. Despite intensive, multimodal therapy, patients with bone sarcomas have poor 5-year survival, close to 50%, with lack of improvement over recent decades. TNF-related apoptosis-inducing ligand (TRAIL), a member of the tumour necrosis factor (TNF) ligand superfamily (TNFLSF), has been found to induce apoptosis in cancer cells while sparing nontransformed cells, and may therefore offer a promising new approach to treatment. We cover the existing preclinical and clinical evidence about the use of TRAIL and other death receptor agonists in bone sarcoma treatment. In vitro studies indicate that TRAIL and other death receptor agonists are generally potent against bone sarcoma cell lines. Ewing's sarcoma cell lines present the highest sensitivity, whereas osteosarcoma and chondrosarcoma cell lines are considered less sensitive. In vivo studies also demonstrate satisfactory results, especially in Ewing's sarcoma xenograft models. However, the few clinical trials in the literature show only low or moderate efficacy of TRAIL in treating bone sarcoma. Potential strategies to overcome the in vivo resistance reported include co-administration with other drugs and the potential to deliver TRAIL on the surface of primed mesenchymal or immune cells and the use of targeted single chain antibodies such as scFv-scTRAIL.
Author(s): Gamie Z, Kapriniotis K, Papanikolaou D, Haagensen E, Da Conceicao Ribeiro R, Dalgarno K, Krippner-Heidenreich A, Gerrand C, Tsiridis E, Rankin KS
Publication type: Note
Publication status: Published
Journal: Cancer Letters
Year: 2017
Volume: 409
Pages: 66-80
Print publication date: 28/11/2017
Online publication date: 06/09/2017
Acceptance date: 28/08/2017
ISSN (print): 0304-3835
ISSN (electronic): 1872-7980
Publisher: Elsevier Ireland Ltd
URL: https://doi.org/10.1016/j.canlet.2017.08.036
DOI: 10.1016/j.canlet.2017.08.036