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Epigenetic reprogramming in liver fibrosis and cancer

Lookup NU author(s): Dr Caroline WilsonORCiD, Professor Derek Mann, Dr Lee Borthwick



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2017 The Authors Novel insights into the epigenetic control of chronic liver diseases are now emerging. Recent advances in our understanding of the critical roles of DNA methylation, histone modifications and ncRNA may now be exploited to improve management of fibrosis/cirrhosis and cancer. Furthermore, improved technologies for the detection of epigenetic markers from patients' blood and tissues will vastly improve diagnosis, treatment options and prognostic tracking. The aim of this review is to present recent findings from the field of liver epigenetics and to explore their potential for translation into therapeutics to prevent disease promoting epigenome reprogramming and reverse epigenetic changes.

Publication metadata

Author(s): Wilson CL, Mann DA, Borthwick LA

Publication type: Review

Publication status: Published

Journal: Advanced Drug Delivery Reviews

Year: 2017

Volume: 121

Pages: 124-132

Print publication date: 01/11/2017

Online publication date: 25/10/2017

Acceptance date: 17/10/2017

ISSN (print): 0169-409X

ISSN (electronic): 1872-8294

Publisher: Elsevier B.V.


DOI: 10.1016/j.addr.2017.10.011