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Identification and analysis of novel methylation quantitative trait loci (mQTLs) in osteoarthritis

Lookup NU author(s): Dr Sarah RiceORCiD, Kat Cheung, Dr Louise Reynard, Professor John LoughlinORCiD


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Purpose: Over 90 independent genome-wide association signals have been reported for osteoarthritis (OA). The vast majority of these risk alleles are thought to mediate their effect through altered expression of a target gene, and are known as expression quantitative trait loci (eQTL). To elucidate the mechanism of risk and target genes at these loci, detailed molecular characterisation of the signals is necessary. Epigenetic mechanisms within chondrocytes can also alter gene expression and underlie regulation of gene expression by single nucleotide polymorphisms (SNPs).

Publication metadata

Author(s): Rice SJ, Cheung K, Reynard LN, Loughlin J

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Osteoarthritis and Cartilage

Year of Conference: 2019

Pages: S23-S91

Print publication date: 01/04/2019

Online publication date: 01/04/2019

Acceptance date: 25/01/2019

ISSN: 1063-4584

Publisher: Elsevier


DOI: 10.1016/j.joca.2019.02.085

Library holdings: Search Newcastle University Library for this item

ISBN: 15229653