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Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

Lookup NU author(s): Dr James ChapmanORCiD, Dr Edward FielderORCiD, Dr Joao Passos

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Abstract

© 2019 Federation of European Biochemical Societies. Cellular senescence and mitochondrial dysfunction have both been defined as classical hallmarks of the ageing process. Here, we review the intricate relationship between the two. In the context of ageing, it is now well regarded that cellular senescence is a key driver in both ageing and the onset of a number of age-related pathologies. Emerging evidence has pinpointed mitochondria as one of the key modulators in the development of the senescence phenotype, particularly the pro-inflammatory senescence associated secretory phenotype (SASP). This review focuses on the contribution of homeostatic mechanisms, as well as of reactive oxygen species and mitochondrial metabolites in the senescence programme. Furthermore, we discuss emerging pathways and mitochondrial-mediated mechanisms that may be influencing the SASP and, subsequently, explore how these may be exploited to open up new therapeutic avenues.

Publication metadata

Author(s): Chapman J, Fielder E, Passos JF

Publication type: Review

Publication status: Published

Journal: FEBS Letters

Year: 2019

Volume: 593

Issue: 13

Pages: 1566-1579

Print publication date: 01/07/2019

Online publication date: 27/06/2019

Acceptance date: 13/06/2019

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Wiley Blackwell

URL: https://doi.org/10.1002/1873-3468.13498

DOI: 10.1002/1873-3468.13498

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