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Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy

Lookup NU author(s): Professor Fiona Oakley, Lucy Gee, Professor Neil Sheerin, Dr Lee Borthwick

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2019 The Authors. Diseases where fibrosis plays a major role accounts for enormous morbidity and mortality and yet we have very little in our therapeutic arsenal despite decades of research and clinical trials. Our understanding of fibrosis biology is primarily built on data generated in conventional mono-culture or co-culture systems and in vivo model systems. While these approaches have undoubtedly enhanced our understanding of basic mechanisms, they have repeatedly failed to translate to clinical benefit. Recently, there had been a push to generate more physiologically relevant platforms to study fibrosis and identify new therapeutic targets. Here we review the state-of-the-art regarding the development and application of 3D complex cultures, bio-printing and precision cut slices to study pulmonary, hepatic and renal fibrosis.


Publication metadata

Author(s): Oakley F, Gee LM, Sheerin NS, Borthwick LA

Publication type: Review

Publication status: Published

Journal: Current Opinion in Pharmacology

Year: 2019

Volume: 49

Pages: 95-101

Print publication date: 01/12/2019

Online publication date: 12/11/2019

Acceptance date: 02/04/2018

ISSN (print): 1471-4892

ISSN (electronic): 1471-4973

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.coph.2019.10.004

DOI: 10.1016/j.coph.2019.10.004


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