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Lookup NU author(s): Professor Fiona OakleyORCiD,
Professor Neil SheerinORCiD,
Dr Lee Borthwick
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2019 The Authors. Diseases where fibrosis plays a major role accounts for enormous morbidity and mortality and yet we have very little in our therapeutic arsenal despite decades of research and clinical trials. Our understanding of fibrosis biology is primarily built on data generated in conventional mono-culture or co-culture systems and in vivo model systems. While these approaches have undoubtedly enhanced our understanding of basic mechanisms, they have repeatedly failed to translate to clinical benefit. Recently, there had been a push to generate more physiologically relevant platforms to study fibrosis and identify new therapeutic targets. Here we review the state-of-the-art regarding the development and application of 3D complex cultures, bio-printing and precision cut slices to study pulmonary, hepatic and renal fibrosis.
Author(s): Oakley F, Gee LM, Sheerin NS, Borthwick LA
Publication type: Review
Publication status: Published
Journal: Current Opinion in Pharmacology
Print publication date: 01/12/2019
Online publication date: 12/11/2019
Acceptance date: 02/04/2018
ISSN (print): 1471-4892
ISSN (electronic): 1471-4973
Publisher: Elsevier Ltd