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Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy

Lookup NU author(s): Dr Natalie Bell, Dr Helen Blair, Dr Simon Bomken

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

Burkitt lymphoma (BL) accounts for almost two-thirds of all B cell non-Hodgkin lymphoma (B-NHL) in children and adolescents and is characterised by a MYC translocation and rapid cell turnover. Intensive chemotherapeutic regimens have been developed in recent decades, including the lymphomes malins B (LMB) protocol, which have resulted in a survival rate in excess of 90%. Recent clinical trials have focused on immunochemotherapy, with the addition of rituximab to chemotherapeutic backbones, showing encouraging results. Despite these advances, relapse and refractory disease occurs in up to 10% of patients and salvage options for these carry a dismal prognosis. Efforts to better understand the molecular and functional characteristics driving relapse and refractory disease may help improve this prognosis. This study has established a paediatric BL patient-derived xenograft (PDX) resource which captures and maintains tumour heterogeneity, may be used to better characterise tumours and identify cell populations responsible for therapy resistance.


Publication metadata

Author(s): Forde S, Matthews JD, Jahangiri L, Lee LC, Prokoph N, Malcolm TIM, Giger OT, Bell N, Blair H, O'Marcaigh A, Smith O, Kenner L, Bomken S, Burke GAA, Turner SD

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2021

Volume: 192

Issue: 2

Pages: 354-365

Print publication date: 01/01/2021

Online publication date: 03/09/2020

Acceptance date: 26/07/2020

Date deposited: 19/10/2020

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell Publishing Ltd

URL: https://doi.org/10.1111/bjh.17043

DOI: 10.1111/bjh.17043

PubMed id: 32880915


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