Publications by Dr Helen Blair - ePrints

Browsing publications by Dr Helen Blair.

Newcastle Authors	Title	Year
Dr Hayden Bell Dr Helen Blair Samantha Jepson Gosling Dr Martin Galler Dan Astley et al.	Combination p53 activation and BCL-x_L/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia	2024
Dr Ricky Tirtakusuma Dr Paul Milne Dr Helen Blair Yuzhe Shi Dr Simon Bomken et al.	Fusion transcripts are present in early progenitor cells in KMT2A-rearranged B-ALL	2024
Dan Coleman Dr Helen Blair Sandeep Potluri Professor Olaf Heidenreich	Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1	2024
Dr Sarah Fordham Dr Wei-Yu Lin Dr Helen Blair Dr Claire Elstob Dr Hayden Bell et al.	Biallelic TET2 mutations confer sensitivity to 5′-azacitidine in acute myeloid leukemia	2023
Dr Paul Sinclair Dr Ruth Cranston Prahlad Raninga Joanna Cheng Rebecca Hanna et al.	Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia	2023
Dr Hayden Bell Dr Helen Blair Mankaran Singh Professor Anthony Moorman Professor Olaf Heidenreich et al.	Targeting WEE1 kinase as a p53-independent therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia	2023
Dr Helen Blair Dr Katarzyna Szoltysek Rachel Cameron Professor Olaf Heidenreich	The MLL-Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AML	2023
Aaron Wilson Sean Hockney Sharon Angel Dr Helen Blair Dr Deepali Pal et al.	A human mesenchymal spheroid prototype to replace moderate severity animal procedures in leukaemia drug testing	2022
Dr Jose Luis Marin-Rubio Dr Maria Duenas Fadic Dr Tiaan Heunis Dr Abeer Dannoura Dr Joe Inns et al.	A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia	2022
Dr Ricky Tirtakusuma Dr Katarzyna Szoltysek Professor Vasily Grinev Dr Sirintra Nakjang Dr Daniel Williamson et al.	Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia	2022
Dr Deepali Pal Dr Helen Blair Sean Hockney Dr Melanie Beckett Mankaran Singh et al.	hiPSC-derived bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukemia	2022
Dr Toni Pringle Dr Corey Chan Dr Saimir Luli Dr Helen Blair Dr Kenneth Rankin et al.	Synthesis and In Vivo Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas	2022
Dr Natalie Bell Dr Helen Blair Dr Simon Bomken	Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy	2021
Yuzhe Shi Melanie Beckett Dr Helen Blair Dr Ricky Tirtakusuma Dr Sirintra Nakjang et al.	Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia	2021
Mankaran Singh Dr Helen Blair Philip Berry Professor Olaf Heidenreich	Multi-drug chemotherapy dose optimisation in preclinical leukaemia models using HPLC-MS/MS	2020
Liz Matheson Huw Thomas Marian Case Dr Helen Blair Rosanna Jackson et al.	Glucocorticoids and selumetinib are highly synergistic in RAS pathway mutated childhood acute lymphoblastic leukemia through upregulation of BIM	2019
Dr Helen Blair Professor Christine Harrison FRCPath FMedSci Dr Lisa Russell	Single cell analysis identifies CRLF2 rearrangements as both early and late events in Down syndrome and non-Down syndrome acute lymphoblastic leukaemia	2019
Dr Helen Blair Professor Olaf Heidenreich	Subtype-specific regulatory network rewiring in acute myeloid leukemia	2019
Dr Deepali Pal Dr Helen Blair Professor Olaf Heidenreich	Targeting the thioredoxin system as a novel strategy against B-cell acute lymphoblastic leukemia	2019
Dr Paul Sinclair Dr Helen Blair Dr Sarra Ryan Dr Lars Buechler Joanna Cheng et al.	Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21	2018
Dr Sarah Fordham Dr Helen Blair Dr Claire Elstob Professor Ruth Plummer Dr Yvette Drew et al.	Inhibition of ATR acutely sensitises acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase	2018
Dr Lynsey McKenzie Hasan Issa Sandeep Potluri Dr Helen Blair Asmida Isa et al.	The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation	2018
Dr Alex Elder Dr Simon Bomken Dr Ian Wilson Dr Helen Blair Dr Simon Cockell et al.	Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia	2017
Dr Aiste McCormick Gavin Cuthbert Dr Rachel O'Donnell Dr Brian Wilson Huw Thomas et al.	Functional characterisation of a novel ovarian cancer cell line, NUOC-1	2017
Dr Richard Noble Dr Natalie Bell Dr Helen Blair Huw Thomas Nicole Phillips et al.	Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and burkitt lymphoma	2017
Dr Britta Vormoor Yvonne Schlosser Dr Helen Blair Abhishek Sharma Sarah Wilkinson et al.	Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2	2017
Dr Lynsey McKenzie Dr Sirintra Nakjang Dr Helen Blair Professor Hermann Josef Vormoor Professor Olaf Heidenreich et al.	Identification of CCND2 As a RUNX1/ETO Target Required for Leukaemic Propagation	2016
Dr Deepali Pal Dr Helen Blair Dr Alex Elder Katie Dormon Dr Kate Rennie et al.	Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia	2016
Dr Alex Elder Dr Klaus Rehe Dr Simon Bomken Dr Paul Sinclair Katie Dormon et al.	The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts.	2016
Dr Paul Sinclair Joanna Cheng Prahlad Raninga Rebecca Hanna Shaun Hollern et al.	A Targeted Functional Clone Tracking Assay for the Identification of Tumour Suppressor Genes in BCP- ALL Implicates the Transcription Factors FOXO3 and PRDM1	2015
Katie Dormon Elda Latif Dr Matthew Bashton Dr Deepali Pal Dr Helen Blair et al.	A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse	2015
Dr Alex Elder Dr Helen Blair Katie Dormon Dr Simon Bomken Dr Simon Cockell et al.	High Abundance of Acute Lymphoblastic Leukaemia Founder Clones Does Not Translate to Functional Heterogeneity	2015
Dr Britta Vormoor Yvonne Schlosser Dr Helen Blair Sarah Wilkinson Professor Herbie Newell et al.	Inhibition of DNA-Repair Enzymes (DNA-Pk and Parp) to Sensitize Ewing Sarcoma to Chemo-And Radiotherapy	2015
Dr Natalie Bell Dr Helen Blair Lisa Price Dr Katrina Wood Professor Hermann Josef Vormoor et al.	Patient-derived xenograft and in vivo bioluminescent modelling of B-cell NHL	2015
Dr Britta Vormoor Henrike Knizia Michael Batey Dr Ian Wilson Dr Petra Dildey et al.	Development of a Preclinical Orthotopic Xenograft Model of Ewing Sarcoma and Other Human Malignant Bone Disease Using Advanced In Vivo Imaging	2014
Dr Natalie Bell Dr Helen Blair Professor Hermann Josef Vormoor Dr Christopher Bacon Dr Vikki Rand et al.	Development of in Vivo Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing	2014
Dr Alex Elder Dr Simon Bomken Dr Helen Blair Professor Hermann Josef Vormoor Professor Olaf Heidenreich et al.	Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia	2014
Dr Simon Bomken Dr Helen Blair Professor Hermann Josef Vormoor Professor Olaf Heidenreich	Preclinical modelling of childhood acute lymphoblastic leukaemia	2014
Professor Julie Irving Elizabeth Matheson Dr Helen Blair Marian Case Isabella Swidenbank et al.	Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition	2014
Michael Batey Dr Frida Ponthan Dr Helen Blair Professor Olaf Heidenreich	The development and evaluation of a series of novel in vivo imaging models of AML for the assessment of drug efficacy	2014
Dr Mitsushiro Nakatomi Dr Helen Blair Katie MacArthur Dr Victor Ruiz-Perez Professor Judith Goodship et al.	Evc regulates a symmetrical response to Shh signaling in molar development	2013
Dr Simon Bomken Dr Lars Buechler Dr Klaus Rehe Dr Frida Ponthan Dr Alex Elder et al.	Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression	2013
Dr Helen Blair Dr Stuart Tompson Yu-Ning Liu Dr Jennifer Campbell Katie MacArthur et al.	Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus	2011
Dr Simon Bomken Dr Lars Buechler Dr Klaus Rehe Dr Frida Ponthan Dr Helen Blair et al.	Lentiviral Transduction of Patient Derived Leukaemic Blasts Allowing In Vivo Bioluminescent Monitoring in An NSG Model of Leukaemia Stem Cell Maintenance	2011
Dr Helen Blair Dr Stuart Tompson Dr Jennifer Campbell Professor Judith Goodship	Evc and Evc2 are interacting cilia transmembrane proteins that modulate Ihh signalling	2009
Dr Victor Ruiz-Perez Dr Helen Blair Dr Colin Miles Dr Heiko Peters Professor Judith Goodship et al.	Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia	2007
Dr Stuart Tompson Dr Victor Ruiz-Perez Dr Helen Blair Dr Michael Wright Professor Judith Goodship et al.	Sequencing EVC and EVC2 identifies mutations in two-thirds of Ellis-van Creveld syndrome patients	2007
Dr Helen Blair Dr Mark Buddles Dr Ann Curtis Professor Judith Goodship	Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy	2004
Professor Judith Goodship Dr Helen Blair Dr Mark Buddles Dr Ann Curtis	Deficiency of synapsin I, a synaptic vesicle protein, causes epilepsy	2003
Dr Victor Ruiz-Perez Dr Stuart Tompson Dr Helen Blair Dr Michael Wright Professor Judith Goodship et al.	Mutations in two nonhomologous genes in a head-to-head configuration cause Ellis-van Creveld syndrome	2003
Dr Helen Blair Emeritus Professor Barry Hirst	Targeting polymerised liposome vaccine carriers to intestinal M cells	2001
Dr Helen Blair	A phenotype map of the mouse X chromosome: Models for human X-linked disease	2000
Dr Helen Blair	Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949 from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome	2000