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Lookup NU author(s): Sarah Hakeem Hakeem,
Dr Nuno MendoncaORCiD,
Dr Terry AsprayORCiD,
Dr Andrew KingstonORCiD,
Emerita Professor Carol Jagger,
Professor John Mathers,
Dr Rachel Duncan,
Professor Thomas Hill
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.
Author(s): Hakeem S, Mendonca N, Aspray T, Kingston A, Ruiz-Martin C, Jagger C, Mathers JC, Duncan R, Hill TR
Publication type: Article
Publication status: Published
Print publication date: 01/09/2020
Online publication date: 09/09/2020
Acceptance date: 07/09/2020
Date deposited: 14/12/2020
ISSN (electronic): 2072-6643
Publisher: MDPI AG
PubMed id: 32916847
Notes: This article belongs to the Special Issue Vitamin D in 2020: Stop or Not Yet?
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