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Lookup NU author(s): Dr Florian Gothe,
Dr Venetia BigleyORCiD,
Dr Joanna Perthen,
Dr Dipayan Mitra,
Professor Sophie HambletonORCiD,
Dr Christopher DuncanORCiD
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Oxford University Press, 2022.
For re-use rights please refer to the publisher's terms and conditions.
We present a case of complete deficiency of the Interferon alpha/beta receptor alpha chain (IFNAR1) in a child with fatal systemic hyperinflammation, apparently provoked by live-attenuated viral vaccination. Such pathologic hyperinflammation, fulfilling criteria for haemophagocytic lymphohistiocytosis, is an emerging phenotype accompanying inborn errors of type I interferon immunity.
Author(s): Gothe F, Hatton CF, Truong L, Klimova Z, Kanderova V, Fejtkova M, Grainger A, Bigley V, Perthen J, Mitra D, Janda A, Fronkova E, Maravicikova D, Hambleton S, Duncan CJA
Publication type: Article
Publication status: Published
Journal: Clinical Infectious Diseases
Print publication date: 01/01/2022
Online publication date: 30/11/2020
Acceptance date: 30/11/2020
Date deposited: 06/02/2021
ISSN (print): 1058-4838
ISSN (electronic): 1537-6591
Publisher: Oxford University Press
PubMed id: 33252644
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