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Lookup NU author(s): Dimitrios Firfilionis, Frances Hutchings, Dr Reza Tamadoni JahromiORCiD, Dr Darren Walsh, Mark Turnbull, Dr Enrique Escobedo-Cousin, Dr Richard Bailey, Dr Johannes Gausden, Aaliyah Patel, Dr Fiona LeBeauORCiD, Professor Andrew Trevelyan, Professor Anthony O'Neill, Professor Marcus Kaiser, Professor Patrick Degenaar, Professor Andrew Jackson
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© Copyright © 2021 Firfilionis, Hutchings, Tamadoni, Walsh, Turnbull, Escobedo-Cousin, Bailey, Gausden, Patel, Haci, Liu, LeBeau, Trevelyan, Constandinou, O'Neill, Kaiser, Degenaar and Jackson. Neuromodulation is an established treatment for numerous neurological conditions, but to expand the therapeutic scope there is a need to improve the spatial, temporal and cell-type specificity of stimulation. Optogenetics is a promising area of current research, enabling optical stimulation of genetically-defined cell types without interfering with concurrent electrical recording for closed-loop control of neural activity. We are developing an open-source system to provide a platform for closed-loop optogenetic neuromodulation, incorporating custom integrated circuitry for recording and stimulation, real-time closed-loop algorithms running on a microcontroller and experimental control via a PC interface. We include commercial components to validate performance, with the ultimate aim of translating this approach to humans. In the meantime our system is flexible and expandable for use in a variety of preclinical neuroscientific applications. The platform consists of a Controlling Abnormal Network Dynamics using Optogenetics (CANDO) Control System (CS) that interfaces with up to four CANDO headstages responsible for electrical recording and optical stimulation through custom CANDO LED optrodes. Control of the hardware, inbuilt algorithms and data acquisition is enabled via the CANDO GUI (Graphical User Interface). Here we describe the design and implementation of this system, and demonstrate how it can be used to modulate neuronal oscillations in vitro and in vivo.
Author(s): Firfilionis D, Hutchings F, Tamadoni R, Walsh D, Turnbull M, Escobedo-Cousin E, Bailey RG, Gausden J, Patel A, Haci D, Liu Y, LeBeau FEN, Trevelyan A, Constandinou TG, O'Neill A, Kaiser M, Degenaar P, Jackson A
Publication type: Article
Publication status: Published
Journal: Frontiers in Neuroscience
Year: 2021
Volume: 15
Online publication date: 10/09/2021
Acceptance date: 16/08/2021
Date deposited: 07/10/2021
ISSN (print): 1662-4548
ISSN (electronic): 1662-453X
Publisher: Frontiers Media SA
URL: https://doi.org/10.3389/fnins.2021.718311
DOI: 10.3389/fnins.2021.718311
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