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Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Lookup NU author(s): Dr Jill Hunter, Dr Jacqueline Butterworth, Helene Sellier, Dr Nicola Hannaway, Dr Saimir Luli, Achilleas FLOUDAS, Dr Niall Kenneth, Adam Moore, Huw ThomasORCiD, Dr Jonathan Coxhead, Leigh Taylor, Dr Peter Leary, Dr Megan Hasoon, Dr Andrew Knight, Professor Neil PerkinsORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Publication metadata

Author(s): Hunter JE, Campbell AE, Butterworth JA, Sellier H, Hannaway NL, Luli S, Floudas A, Kenneth NS, Moore AJ, Brownridge PJ, Thomas HD, Coxhead J, Taylor L, Leary P, Hasoon MSR, Knight AM, Garrett MD, Collins I, Eyers CE, Perkins ND

Publication type: Article

Publication status: Published

Journal: Biochemical Journal

Year: 2022

Volume: 479

Issue: 19

Pages: 2087-2113

Print publication date: 01/10/2022

Online publication date: 19/08/2022

Acceptance date: 19/08/2022

Date deposited: 02/11/2022

ISSN (print): 0264-6021

ISSN (electronic): 1470-8728

Publisher: Portland Press

URL: https://doi.org/10.1042/BCJ20220089

DOI: 10.1042/BCJ20220089

PubMed id: 36240065


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Funding

Funder referenceFunder name
087961
094409
11022Bloodwise (Formerly Leukaemia and Lymphoma Research)
BB/R000182/1
C1443/A12750Cancer Research UK CRUK (open competition)
C1443/A22095Cancer Research UK CRUK (open competition)
BB/M012557/1
C309/A11566
Wellcome Trust

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