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Browsing publications by Huw Thomas

Newcastle AuthorsTitleYearFull text
Kayla Bastian
Maggie Orozco Moreno
Huw Thomas
Dr Kirsty Hodgson
Laura Wilson
et al.		FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors2025
Dr Celine Cano
Professor Jane Endicott
Dr Ian Hardcastle
Dr Claire Jennings
Suzanne Kyle
et al.		Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile2024
Dr Elaine Willmore
Suzanne Kyle
Dr Yan Zhao
Huw Thomas
Dr Kenneth Rankin
et al.		Targeting the MDM2-p53 interaction: Time- and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic index2024
Dr Emma Scott
Emily Archer Goode
Rebecca Garnham
Dr Kirsty Hodgson
Maggie Orozco Moreno
et al.		ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression2023
Dr Nahoum Anthony
Charlotte Jennings
Dr Mathew Martin
Dr Richard Noble
Nicole Phillips
et al.		Targeting cytotoxic agents through EGFR-mediated covalent binding and release2023
Dr Kirsty Hodgson
Maggie Orozco Moreno
Dr Emma Scott
Rebecca Garnham
Karen Livermore
et al.		The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer2023
Dr Emma Scott
Dr Kirsty Hodgson
Kat Cheung
Edward Yo
Laura Wilson
et al.		Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth2023
Dr Jill Hunter
Dr Jacqueline Butterworth
Helene Sellier
Dr Nicola Hannaway
Dr Saimir Luli
et al.		Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance2022
Duncan Miller
Tristan Reuillon
Dr Lauren Molyneux
Dr Tim Blackburn
Dr Noel Edwards
et al.		Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor2022
Dr Richard Noble
Huw Thomas
Dr Yan Zhao
Professor Steve Wedge
Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma2022
Dr Marco Zaki
Dr Sari Alhasan
Dr Ruchi Shukla
Misti McCain
Maja Laszczewska
et al.		Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?2022
Dr Ian Hardcastle
Dr Ruth Bawn
Dr Tim Blackburn
Dr Celine Cano
Dr Sarah Cully
et al.		Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction2021
Alex Bainbridge
Dr Scott Walker
Joseph Smith
Yi Min Ng Ng
Huw Thomas
et al.		IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway2020
Liz Matheson
Huw Thomas
Marian Case
Dr Helen Blair
Rosanna Jackson
et al.		Glucocorticoids and selumetinib are highly synergistic in RAS pathway mutated childhood acute lymphoblastic leukemia through upregulation of BIM2019
Stephanie Myers
Duncan Miller
Dr Lauren Molyneux
Dr Mercedeh Arasta
Dr Ruth Bawn
et al.		Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD42019
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