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Advanced glycation end products in skeletal muscle health and sarcopenia: A systematic review of observational studies

Lookup NU author(s): Dr Antoneta Granic, Dr Christopher HurstORCiD, Lorelle Dismore, Dr Richard DoddsORCiD, Professor Miles WithamORCiD, Professor Sian RobinsonORCiD, Professor Avan SayerORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2022 The Authors. Background: Advanced glycation end products (AGEs) and AGEs receptor (RAGE) may play a role in sarcopenia. This systematic review evaluated the associations between AGEs measured in tissues (skin) by autofluorescence (SAF) and/or circulation (blood, urine) and muscle health outcomes (strength, mass, function) and sarcopenia in observational studies. Methods: MEDLINE, Embase, Scopus and Web of Science were searched for studies reporting associations between AGEs and muscle-related outcomes in community-dwelling adults aged ≥ 30 years (until March 2022). Results: Fourteen cross-sectional and one prospective study were included in the narrative summary. SAF was negatively associated with muscle strength, mass, and physical functioning in adults aged ≥ 30 years (four studies), and muscle mass (three studies), strength, and sarcopenia (one study) in adults aged ≥ 65 years. Circulating AGEs were negatively associated with muscle strength and physical functioning (four studies) and predicted the risk of walking disability (one prospective study), and sarcopenia (one study) in older adults. The role of RAGE in muscle health was inconclusive. Conclusions: SAF and circulating AGEs were negatively associated with muscle-related outcomes in adults aged ≥ 30 years in cross-sectional studies. This finding should be confirmed in well-designed prospective studies investigating sarcopenia, as AGEs represent a potentially modifiable target for intervention.

Publication metadata

Author(s): Granic A, Hurst C, Dismore L, Dodds RM, Witham MD, Robinson SM, Sayer AA

Publication type: Article

Publication status: Published

Journal: Mechanisms of Ageing and Development

Year: 2023

Volume: 209

Print publication date: 01/01/2023

Online publication date: 08/11/2022

Acceptance date: 02/11/2022

Date deposited: 02/11/2022

ISSN (print): 0047-6374

ISSN (electronic): 1872-6216

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.mad.2022.111744


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Funder referenceFunder name
IS-BRC-1215-20001National Institute for Health Research (NIHR)