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Lookup NU author(s): Dr Antoneta Granic, Dr Christopher HurstORCiD, Lorelle Dismore, Dr Richard DoddsORCiD, Professor Miles WithamORCiD, Professor Sian RobinsonORCiD, Professor Avan SayerORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2022 The Authors. Background: Advanced glycation end products (AGEs) and AGEs receptor (RAGE) may play a role in sarcopenia. This systematic review evaluated the associations between AGEs measured in tissues (skin) by autofluorescence (SAF) and/or circulation (blood, urine) and muscle health outcomes (strength, mass, function) and sarcopenia in observational studies. Methods: MEDLINE, Embase, Scopus and Web of Science were searched for studies reporting associations between AGEs and muscle-related outcomes in community-dwelling adults aged ≥ 30 years (until March 2022). Results: Fourteen cross-sectional and one prospective study were included in the narrative summary. SAF was negatively associated with muscle strength, mass, and physical functioning in adults aged ≥ 30 years (four studies), and muscle mass (three studies), strength, and sarcopenia (one study) in adults aged ≥ 65 years. Circulating AGEs were negatively associated with muscle strength and physical functioning (four studies) and predicted the risk of walking disability (one prospective study), and sarcopenia (one study) in older adults. The role of RAGE in muscle health was inconclusive. Conclusions: SAF and circulating AGEs were negatively associated with muscle-related outcomes in adults aged ≥ 30 years in cross-sectional studies. This finding should be confirmed in well-designed prospective studies investigating sarcopenia, as AGEs represent a potentially modifiable target for intervention.
Author(s): Granic A, Hurst C, Dismore L, Dodds RM, Witham MD, Robinson SM, Sayer AA
Publication type: Article
Publication status: Published
Journal: Mechanisms of Ageing and Development
Year: 2023
Volume: 209
Print publication date: 01/01/2023
Online publication date: 08/11/2022
Acceptance date: 02/11/2022
Date deposited: 02/11/2022
ISSN (print): 0047-6374
ISSN (electronic): 1872-6216
Publisher: Elsevier Ireland Ltd
URL: https://doi.org/10.1016/j.mad.2022.111744
DOI: 10.1016/j.mad.2022.111744
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