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Improving outcomes of childhood and young adult non-Hodgkin lymphoma (NHL); twenty-five years of research and collaboration within the framework of the European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL)

Lookup NU author(s): Dr Christopher Bacon, Dr Simon BomkenORCiD



This is the authors' accepted manuscript of an article that has been published in its final definitive form by The Lancet Publishing Group, 2023.

For re-use rights please refer to the publisher's terms and conditions.


The European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) was established 25 years ago with the goal to facilitate clinical trials and research collaborations in the field both within Europe and worldwide. Since its inception, much progress has been made whereby major improvements in outcomes have been achieved. In this Review, we describe the different diagnostic entities of non-Hodgkin lymphoma in children and young adults describing key features of each entity and outlining clinical achievements made in the context of the EICNHL framework. Furthermore, we provide an overview of advances in biopathology with an emphasis on the role of biological studies and how they have shaped available treatments. Finally, for each entity, we describe future goals, upcoming clinical trials, and highlight areas of research that require our focus going forward.

Publication metadata

Author(s): Beishuizen A, Mellgren K, Andrés M, Auperin A, Bacon CM, Bomken S, Burke GAA, Burkhardt B, Brugieres L, Chiang AKS, Damm-Welk C, dAmore E, Horibe K, Kabickova E, Khanam T, Kontny U, Klapper W, Lamant L, Le Deley MC, Loeffen J, Macintyre E, Mann G, Meyer-Wentrup F, Michgehl U, Minard-Colin V, Mussolin L, Oschlies I, Patte C, Pillon M, Reiter A, Rigaud C, Roncery L, Salaverria I, Simonitsch-Klupp I, Uyttebroeck A, Verdu Amoros J, Williams D, Woessmann W, Wotherspoon A, Wrobel G, Zimmermann M, Attarbaschi A, Turner SD

Publication type: Article

Publication status: Published

Journal: The Lancet Haematology

Year: 2023

Volume: 10

Issue: 3

Pages: e213-e224

Print publication date: 01/03/2023

Online publication date: 27/02/2023

Acceptance date: 18/11/2022

Date deposited: 13/03/2023

ISSN (electronic): 2352-3026

Publisher: The Lancet Publishing Group


DOI: 10.1016/S2352-3026(22)00374-X

ePrints DOI: 10.57711/s5xs-rk66

PubMed id: 36858678


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