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The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer

Lookup NU author(s): Dr Beth Adamson, Nicholas Brittain, Dr Laura Walker, Ruaridh Duncan, Dr Sara LuzziORCiD, Dr Pasquale RescignoORCiD, Dr Graham Smith, Dr Elaine WillmoreORCiD, Professor Ian HicksonORCiD, Professor Craig Robson, Dr Stuart McCracken, Professor Rakesh Heer, Dr Luke GaughanORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Publication metadata

Author(s): Adamson B, Brittain N, Walker L, Duncan R, Luzzi S, Rescigno P, Smith GR, McGill S, Burchmore RJS, Willmore E, Hickson I, Robson CN, Bogdan D, Jimenez-Vacas JM, Paschalis A, Welti J, Yuan W, McCracken SR, Heer R, Sharp A, de Bono J, Gaughan L

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Investigation

Year: 2023

Volume: 133

Issue: 22

Print publication date: 15/11/2023

Online publication date: 26/09/2023

Acceptance date: 21/09/2023

Date deposited: 16/11/2023

ISSN (print): 0021-9738

ISSN (electronic): 1558-8238

Publisher: American Society for Clinical Investigation

URL: https://doi.org/10.1172/jci169200

DOI: 10.1172/jci169200

Data Access Statement: RNA-Seq data generated in this study are publicly available at GEO (accession GSE242255). Additional information can be found in the Supplemental Methods https://www.jci.org/articles/view/169200#sd. Values for all data points in graphs are reported in the Supporting Data Values file https://www.jci.org/articles/view/169200#sd. See complete unedited blots in the supplemental material.

PubMed id: 37751307


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Funding

Funder referenceFunder name
Cancer Research UK
Cancer Research UK Newcastle Centre C9380/A25138
Biomedical Research Centre funding to the Royal Marsden
CEO13_2-002the Movember Foundation through the London Movember Centre of Excellence
Experimental Cancer Medicine Centre grant funding from Cancer Research UK and the Department of Health
National Institute for Health and Care Research Biomedical Research Centre funding
National Institute for Health Research (NIHR) Senior Investigator
Prostate Cancer Foundation Young Investigator Award
Prostate Cancer UK
Prostate Cancer Research PCR-6955
the Ken Bell Bursary and JGW Patterson Foundation 12/21 NU009331
the Prostate Cancer Foundation
the Prostrate Cancer Foundation
the Academy of Medical Sciences
the Medical Research Council
the Wellcome Trust

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