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SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample

Lookup NU author(s): Professor Jeremy Parr, Professor Ann Le Couteur

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Abstract

Autism is a severe neurodevelopmental disorder with a complex genetic predisposition. Linkage findings from several genome scans suggest the presence of an autism susceptibility locus on chromosome 2q24–q33, making this region the focus of candidate gene and association studies. Recently, significant association with autism has been reported for single-nucleotide polymorphisms (SNPs) in the SLC25A12 and CMYA3 genes on chromosome 2q. We attempted to replicate these findings in the collection of families from the International Molecular Genetic Study of Autism Consortium (IMGSAC), using the transmission disequilibrium test and case–control comparison. Our study failed to reveal any significant association for the SNPs tested at either locus, suggesting that these variants are unlikely to play a major role in genetic susceptibility to autism in our sample.

Publication metadata

Author(s): Blasi F, Bacchelli E, Carone S, Toma C, Monaco AP, Bailey AJ, Maestrini E, International Molecular Genetic Study of Autism Consortium (IMGSAC)

Publication type: Article

Publication status: Published

Journal: European Journal of Human Genetics

Year: 2006

Volume: 14

Issue: 1

Pages: 123-126

ISSN (print): 1018-4813

ISSN (electronic): 1476-5438

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/sj.ejhg.5201444

DOI: 10.1038/sj.ejhg.5201444

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