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Lookup NU author(s): Dr Christopher Bacon, Dr Simon BomkenORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
Inborn errors of immunity (IEI) are a group of disorders caused by genetically determined defects in the immune system, leading to infections, autoimmunity, autoinflammation and an increased risk of malignancy. In some cases, a malignancy might be the first sign of an underlying IEI. As therapeutic strategies might be different in these patients, recognition of the underlying IEI by the pediatric hemato-oncologist is important. This article, written by a group of experts in pediatric immunology, hemato-oncology, pathology and genetics, aims to provide guidelines for pediatric hemato-oncologists on how to recognize a possible underlying IEI and what diagnostic tests can be performed, and gives some consideration to treatment possibilities.
Author(s): van der Werff ten Bosch J, Hlavackova E, Derpoorter C, Fischer U, Saettini F, Ghosh S, Farah R, Bogaert D, Wagener R, Loeffen J, Bacon CM, Bomken S
Publication type: Article
Publication status: Published
Journal: Pediatric Hematology and Oncology
Year: 2023
Volume: 40
Issue: 2
Pages: 131-146
Online publication date: 01/08/2022
Acceptance date: 27/05/2022
Date deposited: 17/05/2024
ISSN (print): 0888-0018
ISSN (electronic): 1521-0669
Publisher: Taylor & Francis
URL: https://doi.org/10.1080/08880018.2022.2085830
DOI: 10.1080/08880018.2022.2085830
PubMed id: 35913104
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