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Effects of dietary nitrate supplementation on oral health and associated markers of systemic health: a systematic review

Lookup NU author(s): Shatha Alhulaefi, Dr Anthony Watson, Professor Sheena Ramsay, Professor Nicholas JakubovicsORCiD, Dr Kirsten BrandtORCiD, Dr Oliver Shannon



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.Poor oral health can impact an individual’s ability to eat and has been associated with an increased risk of non-communicable diseases. While the benefits of nitrate consumption on oral health were first proposed more than 20 years ago, no systematic review has been published examining effects of dietary nitrate on oral health. This systematic review investigated the effects of dietary nitrate on markers of oral health in vivo in randomized controlled trials (RCTs). Five databases (PubMed, The Cochrane Library, CINAHL, MEDLINE, and SPORTDiscus) were searched from inception until March 2023. Nine articles reporting data on 284 participants were included. Dietary nitrate was provided via beetroot juice in most studies. The duration of the interventions ranged from one day to six weeks. Dietary nitrate supplementation increased the relative abundance of several individual bacterial genera including Neisseria and Rothia. Dietary nitrate supplementation increased salivary pH and decreased salivary acidification following consumption of a sugar-sweetened beverage. Furthermore, dietary nitrate supplementation resulted in a decrease in the gingival inflammation index. The results of this systematic review suggest that dietary nitrate could represent a potential nutritional strategy to positively modify oral health by impacting the oral microbiome, altering salivary pH, and minimizing gingival inflammation.

Publication metadata

Author(s): Alhulaefi SS, Watson AW, Ramsay SE, Jakubovics NS, Matu J, Griffiths A, Kimble R, Siervo M, Brandt K, Shannon OM

Publication type: Review

Publication status: Published

Journal: Critical Reviews in Food Science and Nutrition

Year: 2024

Pages: epub ahead of print

Online publication date: 11/05/2024

Acceptance date: 02/04/2024

ISSN (print): 1040-8398

ISSN (electronic): 1549-7852

Publisher: Taylor and Francis Ltd.


DOI: 10.1080/10408398.2024.2351168