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Lookup NU author(s): Dr Antoneta Granic, Professor Rachel CooperORCiD, Dr Christopher HurstORCiD, Susan HillmanORCiD, Dr Richard DoddsORCiD, Professor Miles WithamORCiD, Professor Avan SayerORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2024. Aim: To investigate cross-sectional and longitudinal associations between glycaemic measures (HbA1c and random glucose) and grip strength (GS) in middle-aged and older adults without prevalent diabetes. Findings: A unit increase in HbA1c was associated with 1–3% higher odds of probable sarcopenia in males across all age groups, and 1–2% higher odds in middle-aged females at baseline. Over 9-year follow-up, males, but not females, with higher baseline HbA1c had decreased odds of having stable high GS pattern, and increased odds of having stable low GS pattern compared with reference (increase or maintained GS within the normal range). Message: Higher HbA1c may be associated with weaker GS in individuals without prevalent diabetes, but the findings warrant replication of the effect on muscle strength when interventions to promote normoglycaemia are trialled.
Author(s): Granic A, Cooper R, Hurst C, Hillman SJ, Dodds RM, Witham MD, Sayer AA
Publication type: Article
Publication status: Published
Journal: European Geriatric Medicine
Year: 2024
Pages: Epub ahead of print
Online publication date: 29/11/2024
Acceptance date: 14/11/2024
Date deposited: 17/12/2024
ISSN (print): 1878-7649
ISSN (electronic): 1878-7657
Publisher: Springer Nature
URL: https://doi.org/ 10.1007/s41999-024-01119-2
DOI: 10.1007/s41999-024-01119-2
Data Access Statement: UK Biobank data were obtained under application number 27567. Analysis code is available upon request to the corresponding author and is not publicly available. UK Biobank data are available to researchers with an approved request (https://www.ukbio bank.ac.uk/register-apply/).
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