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Lookup NU author(s): Dean Ranasinghe, Dr Wei-Yu Lin, Dr Sarah FordhamORCiD, Dr Abrar Alharbi, Dr Nicola Sunter, Dr Claire Elstob, Mohammed Nahari, Dr Yaobo Xu, Dr Catherine Park, Dr Thahira Rahman, Dr Gail Jones, Dr Helen Marr, Professor Graham Jackson, Dr Tobias Menne, Professor Matthew CollinORCiD, Professor Olaf Heidenreich, Dr Amir EnshaeiORCiD, Dumni Gunasinghe, Zoe Hawking, Holly Heslop, Bingjing Di, Imogen Brown, Dr Paul Milne, Jean Norden, Professor Anne Dickinson, Dr Clare LendremORCiD, Professor Ann DalyORCiD, Professor Heather CordellORCiD, Dr Rebecca DarlayORCiD, Professor James AllanORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Acute myeloid leukemia (AML) is a complex hematological malignancy with multiple disease sub-groups defined by somatic mutations and heterogeneous outcomes. Although genome-wide association studies (GWAS) have identified a small number of common genetic variants influencing AML risk, the heritable component of this disease outside of familial susceptibility remains largely undefined. Here we perform a meta-analysis of four published GWAS plus two new GWAS, totalling 4710 AML cases and 12938 controls. We identify a new genome-wide significant risk locus for pan-AML at 2p23.3 (rs4665765; P=1.35x10-8; EFR3B, POMC, DNMT3A, DNAJC27) which also significantly associates with patient survival (P=6.09x10-3). Our analysis also identifies three new genome-wide significant risk loci for disease sub-groups, including AML with deletions of chromosome 5 and/or 7 at 1q23.3 (rs12078864; P=7.0x10-10; DUSP23) and cytogenetically complex AML at 2q33.3 (rs12988876; P=3.28x10-8; PARD3B) and 2p21 (rs79918355; P=1.60x10-9; EPCAM). We also investigated loci previously associated with risk of clonal hematopoiesis (CH) or clonal hematopoiesis of indeterminate potential (CHIP) and identified several variants associated with risk of AML. Our results further inform on AML etiology and demonstrate the existence of disease sub-group specific risk loci.
Author(s): Ranasinghe D, Lin WY, Fordham SE, Alharbi AA, Sunter NJ, Elstob C, Nahari MH, Xu Y, Park C, Hungate E, Quante A, Strauch K, Gieger C, Skol AD, Rahman T, Sucheston-Campbell L, Hahn T, Clay-Gilmour AI, Jones GL, Marr HJ, Jackson GH, Menne T, Collin M, Ivey A, Hills RK, Burnett AK, Russell NH, Fitzgibbon J, Larson RA, Le Beau MM, Stock W, Heidenreich O, Enshaei A, Gunasinghe D, Hawking ZL, Heslop HS, Nandana D, Di B, Plokhuta A, Brown IT, Allsup DJ, Houlston RS, Collins A, Milne P, Norden J, Dickinson AM, Lendrem BC, Daly AK, Palm L, Piechocki K, Jeffries S, Bornhäuser M, Röllig C, Altmann H, Ruhnke L, Kunadt D, Wagenführ L, Cordell HJ, Darlay R, Andersen MK, Fontana MC, Martinelli G, Marconi G, Sanz MÁ, Cervera J, Gomez-Segui I, Cluzeau T, Moreilhon C, Raynaud S, Sill H, Voso MT, Dombret H, Cheok MH, Preudhomme C, Gale RE, Linch DC, Weisinger J, Masszi A, Nowak D, Hofmann WK, Gilkes AF, Porkka K, Milosevic Feenstra JD, Kralovics R, Wang J, Meggendorfer M, Haferlach T, Krizsán S, Bödör C, Parkin BL, Malek SN, Stölzel F, Onel K, Allan JM
Publication type: Article
Publication status: Published
Journal: Blood
Year: 2026
Pages: Epub ahead of print
Online publication date: 02/02/2026
Acceptance date: 19/12/2025
Date deposited: 10/02/2026
ISSN (print): 0006-4971
ISSN (electronic): 1528-0020
Publisher: American Society of Hematology
URL: https://doi.org/10.1182/blood.2025031266
DOI: 10.1182/blood.2025031266
ePrints DOI: 10.57711/6atq-ef26
Data Access Statement: Full summary-level association data from meta-analyses of pan-AML, complex AML, del5/7 AML and cytogenetically normal AML are available via the GWAS catalog (study accession numbers GCST90707271, GCST90707272, GCST90707273, GCST90707274).
PubMed id: 41610418
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