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Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids

Lookup NU author(s): Dr Jon ChapmanORCiD, Dr Andrea MasiORCiD, Dr Lauren BeckORCiD, Dr Hannah Watson, Dr Greg YoungORCiD, Jennifer Doyle, Dr Pawel PalmowskiORCiD, Dr James ConnollyORCiD, Professor Chris LambORCiD, Dr Andrew Porter, Professor Nicholas EmbletonORCiD, Dr John Perry, Professor Janet Berrington, Professor Christopher StewartORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Publication metadata

Author(s): Chapman JA, Masi AC, Beck LC, Watson H, Young GR, Browne HP, Shao Y, Kiu R, Nelson A, Doyle JA, Palmowski P, Lengyel M, Connolly JPR, Lamb CA, Porter A, Lawley TD, Hall LJ, Embleton ND, Perry JD, Berrington JE, Stewart CJ

Publication type: Article

Publication status: Published

Journal: Nature Microbiology

Year: 2026

Pages: Epub ahead of print

Online publication date: 16/03/2026

Acceptance date: 17/02/2026

Date deposited: 23/03/2026

ISSN (electronic): 2058-5276

Publisher: Springer Nature

URL: https://doi.org/10.1038/s41564-026-02297-4

DOI: 10.1038/s41564-026-02297-4

Data Access Statement: The RNA-seq data have been deposited in the Sequencing Read Archive (SRA) under study accession number PRJNA1214204. The proteomics datasets are deposited in MassIVE under submission ID MSV000096907. Sequencing reads for de novo genomes have been deposited in the European Nucleotide Archive (ENA) under accession number ERP187615. Source data are provided with this paper.


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Funding

Funder referenceFunder name
2021 Lister Institute Prize Fellow Award
Newcastle University Academic Career Track (NUACT) Fellowship
Newcastle University UKRI Impact Accelerator Award (IAA-CiC; MR/X50290X/1)
NIHR Newcastle Biomedical Research Centre
Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (221745/Z/20/Z)
Wellcome Investigator Award (220540/Z/20/A)
Wellcome Trust (220540/Z/20/A)

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