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Research updates in cystic fibrosis related diabetes: Understanding pathophysiology, expanding animal and human islet models, and advancing clinical and translational research

Lookup NU author(s): Rebecca Conway, Dr Lee BorthwickORCiD, Professor James ShawORCiD

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Abstract

© 2026 European Cystic Fibrosis Society.In 2024–2025, the Cystic Fibrosis Foundation (US) and Cystic Fibrosis Trust (UK) hosted an International CFRD Consortium round-table webinar series for basic science, translational, and clinical researchers with the goal of sharpening mechanistic understanding of CFRD pathogenesis and prioritizing therapeutic development. This review summarizes the research priorities identified in the International CFRD Consortium, including (i) further investigation into the role of pancreatic fibrosis, vascular abnormalities, and α-cell dysfunction in the development of CFRD; (ii) the creation and refinement of novel animal and human cell- and tissue-based models to understand the complex interplay of exocrine and endocrine cells in the CF pancreas; (iii) development and validation of circulating and imaging biomarkers, together with dynamic glucose testing to explore β-cell function and kinetics in people with CF across the dysglycemia spectrum; and (iv) prospective clinical studies to guide CFRD treatment options and investigate the changing landscape of aging, increasing prevalence of obesity and diabetes and their complications in the era of cystic fibrosis transmembrane conductance regulator (CFTR) modulators. Collectively, these priorities aim to accelerate transition from mechanism to intervention and expand evidence-based care for people with CF at risk of, or living with, CFRD.

Publication metadata

Author(s): Putman MS, Hull-Meichle RL, Waters SA, Tuggle K, Sommer P, Conway R, Borthwick LA, Knudsen JG, Dean ED, Stanley SA, Sun X, Engelhardt JF, Leir S-H, Eliasson L, Nielsen BU, Stefanovski D, Brennan A, Boughton CK, Kelly A, Moheet A, Shaw JAM

Publication type: Review

Publication status: Published

Journal: Journal of Cystic Fibrosis

Year: 2026

Issue: ePub ahead of Print

Online publication date: 05/04/2026

Acceptance date: 25/03/2026

ISSN (print): 1569-1993

ISSN (electronic): 1873-5010

Publisher: Elsevier B.V.

URL: https://doi.org/10.1016/j.jcf.2026.03.021

DOI: 10.1016/j.jcf.2026.03.021

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