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Lookup NU author(s): Dr Fiona LeBeau,
Professor Miles Whittington
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In recent years, several key studies have shed new light on the roles of electrical signaling via gap junctions between neurons in the adult brain. In particular, it is now clear that electrical signaling is important, if not essential, for the generation of a wide variety of different network interactions which may underlie rhythmic activity, of cognitive relevance, seen in EEG recordings. Two types of such rhythmic activity observed in the hippocampus both in vivo and in vitro are gamma frequency (30–80 Hz) oscillations and ultrafast (>80 Hz) “ripple” oscillations. Several lines of work, discussed here, show that gap junction-mediated signaling plays a central role in the generation of both these types of network activity. Recent work also now suggests that a number of different, anatomically discrete, gap junction-mediated networks may exist which could both function and be modulated independently.
Author(s): LeBeau FEN; Whittington MA; Traub RD; Monyer H; Buhl EH
Publication type: Article
Publication status: Published
Journal: Brain Research Bulletin
ISSN (print): 0361-9230
ISSN (electronic): 1873-2747
Publisher: Elsevier Inc.
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