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Alcoholic liver disease: New insights into mechanisms and preventative strategies

Lookup NU author(s): Dr Stephen Stewart, Professor David Jones, Professor Chris Day


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Alcoholic liver disease has a known aetiology but a complex pathogenesis. It is an extremely common disease with a high mortality, but the reason why only a relatively small proportion of heavy drinkers progress to advanced disease remains elusive. Accumulating evidence points towards an elaborate interplay between metabolism, inflammation and immunity in the development of steatosis, hepatitis and fibrosis. These complex pathways leading to liver injury offer many potential susceptibility loci, as well as sites for potential therapeutic intervention.

Publication metadata

Author(s): Stewart S, Jones D, Day CP

Publication type: Review

Publication status: Published

Journal: Trends in Molecular Medicine

Year: 2001

Volume: 7

Issue: 9

Pages: 408-413

ISSN (print): 1471-4914

ISSN (electronic): 1471-499X


DOI: 10.1016/S1471-4914(01)02096-2

PubMed id: 11530336