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Lookup NU author(s): Dr Linda Hogarth,
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DNA polymerase β, one of the most inaccurate DNA synthesizing enzymes, has been shown to confer genetic instability when up-regulated in cells, a situation found in several human cancers. Here, we demonstrated that enhanced activity and expression of this enzyme occur in the human ovarian tumor 2008/C13*5.25 cells, which are resistant to the antitumor agent cisplatin and hypersensitive to 6-thioguanine. We found that translesion synthesis across platinated DNA crosslinks as well as increased incorporation into DNA of 6-thioguanine took place in the 2008/C13*5.25 cells compared to the parental 2008 cells. Such features being molecular signatures of DNA polymerase β, these findings suggest that deregulation of its expression in cancer cells may contribute to the modulation of the response to antitumor treatments and therefore to tumor progression.
Author(s): Bergoglio V, Canitrot Y, Hogarth LA, Minto CLJ, Howell SB, Cazaux C, Hoffmann JS
Publication type: Article
Publication status: Published
Print publication date: 27/09/2001
ISSN (print): 0950-9232
ISSN (electronic): 1476-5594
PubMed id: 11593426
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