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GvHD risk assessment in hematopoietic stem cell transplantation: Role of cytokine gene polymorphisms and an In Vitro human skin explant model

Lookup NU author(s): Professor Anne Dickinson, Dr Jennifer Cavet, Dr Hannah Cullup, Dr Xiao WangORCiD, Dr Peter Middleton


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This present review concentrates on the recent results investigating the role of certain cytokine gene polymorphisms, including tumor necrosis factor α, interferon γ, interleukin-6 (IL-6), IL-10, and IL-1 receptor antagonist, in allogeneic stem cell transplantation. The review discusses their potential role in predicting outcome and the development of a genetic risk index for graft-versus-host disease in human leukocyte antigen matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest that certain polymorphisms may be associated with more severe disease. © American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.

Publication metadata

Author(s): Dickinson AM, Cavet J, Cullup H, Wang XN, Sviland L, Middleton PG

Publication type: Article

Publication status: Published

Journal: Human Immunology

Year: 2001

Volume: 62

Issue: 11

Pages: 1266-1276

Print publication date: 01/01/2001

ISSN (print): 0198-8859

ISSN (electronic): 1879-1166

Publisher: Elsevier


DOI: 10.1016/S0198-8859(01)00324-X

PubMed id: 11704290


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