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Predicting outcome in hematological stem cell transplantation

Lookup NU author(s): Professor Anne Dickinson, Dr Jennifer Cavet, Dr Hannah Cullup, Dr Xiao WangORCiD, Dr Mark Jarvis, Dr Peter Middleton


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This review summarizes recent results investigating the role of certain cytokine gene polymorphisms, including those of TNF-α, IFN-γ, IL-6, IL-10 and IL-1 receptor antagonist (IL-1Ra), in allogeneic stem cell transplantation. It discusses their role in predicting outcome and the development of a genetic risk index for graft versus host disease (GvHD) in HLA-matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest that certain cytokine gene polymorphisms may be associated with more severe disease.

Publication metadata

Author(s): Dickinson AM, Cavet J, Cullup H, Wang XN, Jarvis M, Sviland L, Middleton PG

Publication type: Review

Publication status: Published

Journal: Archivum Immunologiae et Therapiae Experimentalis

Year: 2002

Volume: 50

Issue: 6

Pages: 371-378

Print publication date: 01/01/2002

ISSN (print): 0004-069X

ISSN (electronic): 1661-4917

PubMed id: 12546063