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Lookup NU author(s): Dr Meiyi Pu,
Dr Felicity May,
Dr Marie-Helene Ruchaud,
Professor Bruce Westley
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TFF1 is one of three human trefoil proteins expressed principally in the gastrointestinal tract in normal tissues. TFF1 protects the gastric mucosa against damage as a result of its ability to facilitate reconstitution of damaged gastric mucosa and its involvement in the secretion and structure of gastric mucus. The most biologically active molecular form in cell culture and animal models tested is a dimer formed by a disulfide bond between two cysteine residues close to the C terminus of the protein. We have therefore developed an assay for this form of TFF1 which should facilitate its measurement in biological samples. © 2004 Elsevier Inc. All rights reserved.
Author(s): Pu M, May FEB, Playford R, Ruchaud-Sparagano M, Westley BR
Publication type: Article
Publication status: Published
Print publication date: 01/05/2004
ISSN (print): 0196-9781
ISSN (electronic): 1873-5169
PubMed id: 15177866
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