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Browsing publications by Dr Marie-Helene Ruchaud.

Newcastle AuthorsTitleYearFull text
Dr Jack Leslie
Dr Marie-Helene Ruchaud
Amy Collins
Leena Habiballa
Dr Gabi Saretzki
et al.
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner2021
Jonathan Scott
Dr Marie-Helene Ruchaud
Dr Kate Musgrave
Dr Stephen Wright
Dr John Perry
et al.
Phosphoinositide 3-kinase δ inhibition improves neutrophil bacterial killing in critically ill patients at high risk of infection2021
Dr Marie-Helene Ruchaud
Jonathan Scott
Professor John Simpson
C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling2020
Dr Jim Macfarlane
Dr Marie-Helene Ruchaud
Jonathan Scott
Professor John Simpson
Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury2020
Dr Kathryn Musgrave
Jonathan Scott
Dr Wezi Sendama
Dr Patrick Kesteven
Dr Marie-Helene Ruchaud
et al.
The differential surface expression of tissue factor between monocyte subsets2020
Dr Laura Jardine
Dr Sarah Wiscombe
Dr Gary Reynolds
Dr David McDonald
Andrew Fuller
et al.
Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets to the alveolar airspace.2019
Jason Powell
Dr James Garnett
Dr Michael Mather
Dr Faye Cooles
Dr Bernard Verdon
et al.
Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients2018
Dr John Widdrington
Dr Aurora Gomez Duran
Dr Angela Pyle
Dr Marie-Helene Ruchaud
Jonathan Scott
et al.
Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses2018
Dr Emma Pinder
Dr Anthony Rostron
Dr Tom Hellyer
Dr Marie-Helene Ruchaud
Jonathan Scott
et al.
Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis2018
Dr John Widdrington
Dr Aurora Gomez Duran
Dr Jannetta Steyn
Dr Angela Pyle
Dr Marie-Helene Ruchaud
et al.
Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ2017
Jonathan Scott
Dr Jim Macfarlane
Dr Tom Hellyer
Dr Anthony Rostron
Dr Marie-Helene Ruchaud
et al.
Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by beta(2)-agonists, corticosteroids, and critical illness2016
Dr Marie-Helene Ruchaud
Dr Jenny Grant
Dr Logan Thirugnanasothy
Sasiharan Sithamparanathan
Emeritus Professor Nick Europe-Finner
et al.
Investigation Of Neutrophil Function In Ipah Patients2016
Dr Emma Pinder
Dr Anthony Rostron
Thomas Hellyer
Dr Marie-Helene Ruchaud
Jonathan Scott
et al.
Randomised Controlled Trial Of Granulocyte Macrophage Colony Stimulating Factor In Critically Ill Patients With Impaired Neutrophil Function2016
Dr Tom Hellyer
Dr Simon Baudouin
Dr Stephen Wright
Melinda Jeffels
Dr Marie-Helene Ruchaud
et al.
Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia2015
Dr Jim Macfarlane
Jonathan Scott
Dr Marie-Helene Ruchaud
Dr Anjam Khan
Professor John Simpson
et al.
Src/bcr-abl Inhibition with Dasatinib in Sterile and Non-Sterile Acute Lung Inflammation2014
Dr Marie-Helene Ruchaud
Jonathan Scott
Professor John Simpson
MPLA inhibits release of cytotoxic mediators from human neutrophils while preserving efficient bacterial killing2014
Dr Catherine Popplewell
Dr Marie-Helene Ruchaud
Jonathan Scott
Emeritus Professor Nick Europe-Finner
Professor John Simpson
et al.
Carboplatin and Gemcitabine Impair Neutrophil Phagocytic Function2013
Dr Marie-Helene Ruchaud
Dr Katy Hester
Dr Jim Macfarlane
Emeritus Professor Nick Europe-Finner
Professor John Simpson
et al.
Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis2013
Dr Jim Macfarlane
Dr Marie-Helene Ruchaud
Jonathan Scott
Dr David Bulmer
Dr Anjam Khan
et al.
Src Kinase Inhibition Attenuates Neutrophil Degranulation Without Impairing Bacterial Killing: A Possible Therapeutic Strategy for Acute Lung Injury?2013
Dr Marie-Helene Ruchaud
Professor Brendan Kenny
Proteasome-independent degradation of canonical NFκB complex components by the NleC protein of pathogenic Escherichia coli2011
Dr Marie-Helene Ruchaud
Dr Paul Dean
Professor Brendan Kenny
The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-κB Activity by Targeting TNFα Receptor-Associated Factors2011
Dr Marie-Helene Ruchaud
Professor Brendan Kenny
Enteropathogenic Escherichia coli (EPEC) inactivate innate immune responses prior to compromising epithelial barrier function2007
Dr Marie-Helene Ruchaud
A critical threshold of β2-integrin engagement regulates augmentation of cytokine-mediated superoxide anion release2004
Dr Meiyi Pu
Dr Felicity May
Dr Marie-Helene Ruchaud
Professor Bruce Westley
Development of a two-site ELISA assay for the dimeric form of human TFF12004
Dr Marie-Helene Ruchaud
Professor Bruce Westley
Dr Felicity May
The trefoil protein TFF1 is bound to MUC5AC in human gastric mucosa2004
Dr Marie-Helene Ruchaud
Soluble E-selectin acts in synergy with platelet-activating factor to activate neutrophil beta 2-integrins. Role of tyrosine kinases and Ca2+ mobilization2000
Dr Marie-Helene Ruchaud
Differential effects of bacterial lipopolysaccharides upon neutrophil function1998
Dr Marie-Helene Ruchaud
Mapping the epitope of a functional P-selectin monoclonal antibody (LYP20) to a short complement-like repeat (SCR 4) domain: use of human-mouse chimaera and homologue-replacement mutagenesis1998
Dr Marie-Helene Ruchaud
Potential pro-inflammatory effects of soluble E-selectin upon neutrophil function1998
Dr Marie-Helene Ruchaud
Activation of neutrophil function via CD66: differential effects upon beta 2 integrin mediated adhesion1997
Dr Marie-Helene Ruchaud
CD66: role in the regulation of neutrophil effector function1996