Toggle Main Menu Toggle Search

Open Access padlockePrints

A 7-year-old boy with midline cerebellar mass

Lookup NU author(s): Dr Jayne Lamont, Professor Deborah Tweddle, Professor Andrew Pearson, Professor Steven CliffordORCiD, Professor David Ellison


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


A boy aged 7 years was found to have a tumor arising from the roof of the fourth ventricle. Histopathologically, part of the tumor appeared as a PNET, while neuroglial tissue, striated and smooth muscle, cartilage and small glandular structures were present in other regions. Tumor cells in both primitive and mature elements showed a loss of chromosome 17p accompanied by a gain of 17q, a pattern consistent with the presence of an isochromosome 17q. This abnormality is not characteristic of intracranial germ cell tumors, but is present in over 30% of medulloblastomas. On the basis of the histologic and genetic abnormalities, we propose a diagnosis of PNET with multilineal differentiation.

Publication metadata

Author(s): Ismail A, Lamont JM, Tweddle DA, Pearson ADJ, Clifford SC, Ellison DW

Publication type: Article

Publication status: Published

Journal: Brain Pathology

Year: 2005

Volume: 15

Issue: 3

Pages: 261-261

Print publication date: 01/07/2005

ISSN (print): 1015-6305

ISSN (electronic): 1750-3639

PubMed id: 16196393