Professor Steven Clifford
| Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage | 2024 |
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Professor Steven Clifford
| Correction to: Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage (Nature Communications, (2024), 15, 1, (269), 10.1038/s41467-023-44117-x) | 2024 |
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Jemma Castle Dr Edward Fielder Mankaran Singh Professor Roderick Skinner Professor Thomas von Zglinicki et al. | In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma | 2024 |
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Dr Claire Keeling Dr Jack Goddard Dr Ed Schwalbe Professor Simon Bailey Dr Debbie Hicks et al. | MDB-31. The clinical significance of sub-total surgical resection in childhood medulloblastoma: a multi-cohort analysis of 1100 patients. | 2024 |
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Dr Marion Mateos Dr Daniel Williamson Dr Marina Danilenko Dr Jack Goddard Dr Stephen Crosier et al. | MDB-64. Novel transcripts associate with survival in childhood medulloblastoma. | 2024 |
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Dr Florence Burté Magretta Adiamah Dr Fatma Scerif Dr Debbie Hicks Dr Ed Schwalbe et al. | Metabolite profiles of medulloblastoma for rapid and non-invasive detection of molecular disease groups | 2024 |
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Professor Steven Clifford
| Risk factors for domain-specific neurocognitive outcome in pediatric survivors of a brain tumor in the posterior fossa-Results of the HIT 2000 trial | 2024 |
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Dr Claire Keeling Dr Jack Goddard Dr Ed Schwalbe Professor Simon Bailey Dr Debbie Hicks et al. | The clinical significance of sub-total surgical resection in childhood medulloblastoma: a multi-cohort analysis of 1100 patients | 2024 |
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Dr Stacey Richardson Dean Thompson Professor Steven Clifford Dr Rebecca Hill
| ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors | 2023 |
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Professor Steven Clifford Dr Ed Schwalbe
| Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome | 2023 |
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James Hacking Dr Dean Thompson Dr Ed Schwalbe Professor Steven Clifford Dr Daniel Williamson et al. | Deriving a continuum score for group 3 and 4 medulloblastoma tumor samples analyzed via RNA-sequencing or DNA methylation microarray | 2023 |
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Professor Steven Clifford
| Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging | 2023 |
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Dr Jack Goddard Jemma Castle Emily Southworth Anya Fletcher Dr Stephen Crosier et al. | Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification | 2023 |
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Professor Simon Bailey Professor Steven Clifford
| Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study | 2023 |
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Dr Daniel Williamson Dr Ed Schwalbe Professor Simon Bailey Professor Steven Clifford
| Timing is everything: A connection between medulloblastoma prognosis and foetal cerebellar development | 2023 |
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Dr Daniel Williamson Professor Steven Clifford
| Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma | 2022 |
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Dr Stacey Richardson Professor Steven Clifford
| Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation | 2022 |
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Dr Stacey Richardson Dr Rebecca Hill Professor Steven Clifford
| Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma | 2022 |
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Professor Simon Bailey Professor Steven Clifford
| How Can Genomic Innovations in Pediatric Brain Tumors Transform Outcomes in Low- and Middle-Income Countries? | 2022 |
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Dr Jack Goddard Jemma Castle Emily Southworth Anya Fletcher Dr Stephen Crosier et al. | MEDB-71. Molecular characterisation of Group 4 medulloblastoma improves risk-stratification and its biological understanding | 2022 |
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Dr Daniel Williamson Dr Ed Schwalbe Dr Debbie Hicks Dr Janet Lindsey Dr Stephen Crosier et al. | Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development | 2022 |
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Dr Rebecca Hill Professor Steven Clifford Professor Simon Bailey
| Relapsed medulloblastoma in pre-irradiated patients: Current practice for diagnostics and treatment | 2022 |
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Dr Marina Danilenko Dr Claire Keeling Dr Stephen Crosier Dr Martina Finetti Dr Daniel Williamson et al. | Single-cell DNA sequencing identifies risk-associated clonal complexity and evolutionary trajectories in childhood medulloblastoma development | 2022 |
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Professor Simon Bailey Professor Steven Clifford
| Acceptance and commitment therapy for young brain tumour survivors: Study protocol for an acceptability and feasibility trial | 2021 |
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Dr Stephen Crosier Dr Debbie Hicks Dr Ed Schwalbe Dr Daniel Williamson Amanda Smith et al. | Advanced molecular pathology for rare tumours: A national feasibility study and model for centralised medulloblastoma diagnostics | 2021 |
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Professor Simon Bailey Professor Steven Clifford Dr Dipayan Mitra
| Combining multi-site magnetic resonance imaging with machine learning predicts survival in pediatric brain tumors | 2021 |
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Professor Steven Clifford
| Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation | 2021 |
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Dr Marina Danilenko Professor Steven Clifford Dr Ed Schwalbe
| Inter and intra-tumoral heterogeneity as a platform for personalized therapies in medulloblastoma | 2021 |
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Professor Steven Clifford
| SIOP PNET5 MB trial: History and concept of a molecularly stratified clinical trial of risk-adapted therapies for standard-risk medulloblastoma | 2021 |
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Dr Debbie Hicks Dr Reza Rafiee Dr Ed Schwalbe Dr Christopher Howell Dr Janet Lindsey et al. | The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second-generation subtypes | 2021 |
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Dr Ed Schwalbe Dr Debbie Hicks Professor Steven Clifford
| Effects of the growth pattern of medulloblastoma on short-term neurological impairments after surgery: Results from the prospective multicenter HIT-SIOP PNET 4 study | 2020 |
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Dr Matthew Selby Dr Daniel Williamson Professor Steven Clifford
| Erratum: Author Correction: VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells (Communications biology (2020) 3 1 (579)) | 2020 |
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Professor Steven Clifford
| Evaluation of Prognostic Factors and Role of Participation in a Randomized Trial or a Prospective Registry in Pediatric and Adolescent Nonmetastatic Medulloblastoma – A Report From the HIT 2000 Trial | 2020 |
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Dr Yura Grabovska Dr Stephen Crosier Dr Martina Finetti Dr Ed Schwalbe Dr Rebecca Hill et al. | Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity | 2020 |
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Dr Rebecca Hill Dr Stacey Richardson Dr Ed Schwalbe Dr Debbie Hicks Dr Janet Lindsey et al. | Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study | 2020 |
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Professor Steven Clifford
| VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells | 2020 |
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Dr Rebecca Hill Professor Steven Clifford Yura Grabovska Dr Daniel Williamson
| DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment: a population-based study | 2019 |
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Professor Steven Clifford Dr Ed Schwalbe Dr Debbie Hicks
| Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort | 2019 |
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Professor Steven Clifford Professor David Ellison
| Medulloblastoma | 2019 |
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Dr Ed Schwalbe Dr Daniel Williamson Dr Janet Lindsey Dr Rebecca Hill Dr Debbie Hicks et al. | Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes | 2019 |
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Dr Daniel Williamson Dr Christopher Jones Professor Steven Clifford
| Biological material collection to advance translational research and treatment of children with CNS tumours: position paper from the SIOPE Brain Tumour Group | 2018 |
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Dr Ed Schwalbe Dr Debbie Hicks Professor Steven Clifford
| Prognostic impact of whole chromosomal 1 aberration signatures in standard-risk non-WNT/non-SHH medulloblastoma: a retrospective molecular analysis of the HIT-SIOP-PNET4 clinical trial | 2018 |
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Professor Steven Clifford Dr Debbie Hicks Dr Janet Lindsey Dr Rebecca Hill
| Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours | 2017 |
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Dr Ed Schwalbe Dr Debbie Hicks Dr Reza Rafiee Dr Matthew Bashton Dr Amir Enshaei et al. | Minimal methylation classifier (MIMIC): A novel method for derivation and rapid diagnostic detection of disease-associated DNA methylation signatures | 2017 |
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Dr Ed Schwalbe Dr Janet Lindsey Dr Sirintra Nakjang Dr Stephen Crosier Amanda Smith et al. | Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study | 2017 |
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Dr Matthew Selby Dr Daniel Williamson Professor Steven Clifford
| TAp73 is a marker of glutamine addiction in medulloblastoma | 2017 |
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Dr Stephen Crosier Dr Debbie Hicks Dr Ed Schwalbe Dr Daniel Williamson Sarah Nicholson et al. | Centralised Molecular Pathology for Rare Tumours: A National Feasibility Study of Real-Time Medulloblastoma Diagnostics | 2016 |
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Professor Steven Clifford
| Distinct Gene Fusions Segregate Sub-Classes of CNS-PNETs | 2016 |
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Professor Simon Bailey Dr Janet Lindsey Professor Steven Clifford
| Divergent clonal selection dominates medulloblastoma at recurrence | 2016 |
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Professor Steven Clifford Dr Stephen Crosier Dr Debbie Hicks Stewart Nicholson Dr Nicholas Bown et al. | Establishment of national real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma (MB) | 2016 |
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Professor Steven Clifford
| Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled SIOP-E and head start data | 2016 |
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Dr Ed Schwalbe Dr Debbie Hicks Professor Steven Clifford
| Health-Related Quality of Life (HRQoL) in HIT-SIOP-PNET4 trial survivors: differences between medulloblastoma molecular subgroups | 2016 |
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Professor Steven Clifford
| Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours | 2016 |
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Dr Debbie Hicks Dr Ed Schwalbe Dr Stephen Crosier Professor Simon Bailey Dr Daniel Williamson et al. | Identification of medulloblastoma molecular subgroups using metabolite profiles | 2016 |
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Dr Martina Finetti Matthew Selby Dr Matthew Bashton Dr Ruth Cranston Dr Stephen Crosier et al. | Integrated pathway analysis of malignant rhabdoid tumour identifies key SMARCB1-pathways and therapeutic opportunities | 2016 |
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Dr Martina Finetti Alicia Del Carpio Pons James Barker James Wood Dr Sirintra Nakjang et al. | Integrated pathway analysis of rhabdoid tumor subtypes identifies key SMARCB1-dependencies and therapeutic opportunities | 2016 |
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Matthew Selby Dr Martina Finetti Dr Matthew Bashton Dr Ruth Cranston Alicia Del Carpio Pons et al. | Investigating the biology of atypical teratoid/rhabdoid tumors by whole genome CRISPR/CAS9 screening | 2016 |
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Dr Janet Lindsey Dr Rebecca Hill Dr Ed Schwalbe Dr Christopher Howell Dr Reza Rafiee et al. | Molecular and Prognostic Heterogeneity within MYC and MYCN Amplified Medulloblastomas | 2016 |
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Dr Debbie Hicks Professor Steven Clifford
| Molecular Subgrouping of Medulloblastoma with nanostring technology: A feasibility study for routine real-time procedures | 2016 |
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Professor Steven Clifford
| Relapse patterns and outcome after relapse in standard risk medulloblastoma: a report from the HIT-SIOP-PNET4 study | 2016 |
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Professor Simon Bailey Professor Steven Clifford
| Risk stratification of childhood medulloblastoma in the molecular era: the current consensus | 2016 |
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Dr Ed Schwalbe Dr Debbie Hicks Dr Reza Rafiee Dr Matthew Bashton Dr Amir Enshaei et al. | Routine Diagnostic Medulloblastoma Subgrouping Using Low-Cost, Low-Input DNA Methylomics: Application to Trials Cohorts Previously Refractory-to-Analysis | 2016 |
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Dr Ed Schwalbe Dr Debbie Hicks Dr Reza Rafiee Dr Matthew Bashton Dr Amir Enshaei et al. | Routine molecular subgrouping of medulloblastoma: Bridging the divide between research and the clinic using low-cost, mass spectrometry-based DNA methylomics | 2016 |
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Dr Debbie Hicks Dr Reza Rafiee Dr Ed Schwalbe Dr Christopher Howell Dr Janet Lindsey et al. | Subgroup-Directed Stratification of Risk in Infant Medulloblastoma | 2016 |
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Dr Daniel Williamson Dr Janet Lindsey Dr Debbie Hicks Dr Stephen Crosier Amanda Smith et al. | The Transcriptional Landscape of Medulloblastoma: Group 3 and Group 4 Tumours Comprise a Single Clinically Significant Expression Continuum | 2016 |
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Professor Steven Clifford Dr Ed Schwalbe Dr Debbie Hicks Kieran O'Toole Sarah Nicholson et al. | Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial | 2015 |
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Professor Steven Clifford Dr Ed Schwalbe Dr Debbie Hicks Kieran O'Toole Sarah Nicholson et al. | Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial | 2015 |
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Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Dr Karen Barker Dr Daniel Williamson et al. | Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease | 2015 |
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Dr Janet Lindsey Dr Ed Schwalbe Matthew Selby Dr James Hayden Dr Daniel Williamson et al. | Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance | 2015 |
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Dr Ed Schwalbe Professor Steven Clifford
| DNA Methylation Analysis of Paediatric Low-Grade Astrocytomas Identifies a Tumour-Specific Signature at a Set of Enhancers | 2015 |
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Dr Al Gabriel Fadhel Alsaid Naji Dr Ed Schwalbe Dr Sirintra Nakjang Dr Simon Cockell et al. | Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia | 2015 |
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Dr Janet Lindsey Dr Ed Schwalbe Sandeep Potluri Professor Simon Bailey Dr Daniel Williamson et al. | TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours | 2014 |
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Dr Martina Finetti Alicia Del Carpio Pons Ben Skalkoyannis Matthew Selby Amanda Smith et al. | A Systems Biology Approach to Identify Mechanism of Tumourigenesis Caused by Loss of SMARCB1 in Malignant Rhabdoid Tumors (BACR28) | 2014 |
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Professor Simon Bailey Professor David Ellison Professor Steven Clifford
| An Exploration of Associations between Health Related Quality of Life and Medulloblastoma Molecular Subgroup Status in Survivors from the SIOP UKCCSG PNET3 Trial | 2014 |
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Dr Martina Finetti Matthew Selby Dr Stephen Crosier Ben Skalkoyannis Professor Simon Bailey et al. | Characterising critical pathways in ATRT tumourigenesis: a genome-wide analysis of primary tumours and functional genomic models | 2014 |
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Professor Steven Clifford
| CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity | 2014 |
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Dr Janet Lindsey Dr Ed Schwalbe Dr James Hayden Professor David Ellison Dr Daniel Williamson et al. | Cross-Species Epigenetics Identifies a Critial Role for VAV1 in the Maintenance of Sonic Hedgehog Subgroup Medulloblastomas | 2014 |
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Professor Simon Bailey Dr Janet Lindsey Professor Steven Clifford
| Cytogenetic Prognostication Within Medulloblastoma Subgroups | 2014 |
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Professor Steven Clifford
| Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system | 2014 |
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Professor Simon Bailey Professor David Ellison Professor Steven Clifford
| Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors | 2014 |
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Dr Martina Finetti Ben Skalkoyannis Matthew Selby Dr Stephen Crosier Professor Simon Bailey et al. | Mechanism of tumourigenesis caused by loss of SMARCB1 in malignant rhabdoid tumors | 2014 |
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Professor Simon Bailey Professor Steven Clifford Dr Daniel Williamson
| Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group | 2014 |
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Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Dr Daniel Williamson Dr Sarra Ryan et al. | MYC and TP53 defects emerge and interact at medulloblastoma relapse, define rapidly progressive disease and can be targeted therapeutically | 2014 |
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Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Dr Karen Barker Dr Daniel Williamson et al. | MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically | 2014 |
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Dr Martina Finetti Matthew Selby Alicia Del Carpio Pons Ben Skalkoyannis Amanda Smith et al. | Next-generation sequencing identifies the mechanism of tumourigenesis caused by loss of SMARCB1 in malignant rhabdoid tumours | 2014 |
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Professor Steven Clifford
| Prognostic Factors in Childhood CNS-PNET and Pineblastoma: An International Meta-Analysis of Original Clinical Data | 2014 |
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Dr Ed Schwalbe Dr Debbie Hicks Dr Reza Rafiee Dr Amir Enshaei Sandeep Potluri et al. | Routine molecular subgrouping of medulloblastoma: Bridging the divide between research and the clinic using low-cost DNA methylomics | 2014 |
|
Professor Steven Clifford
| WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma | 2014 |
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Professor Steven Clifford Dr Stephen Crosier Sarah Nicholson Dr Nicholas Bown
| A national feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma | 2013 |
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Dr Ed Schwalbe Dr Daniel Williamson Dr Janet Lindsey Dolores Hamilton Sarra Ryan et al. | DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies | 2013 |
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Dr Ed Schwalbe Dr James Hayden Dr Janet Lindsey Dr Rebecca Hill Sarah Nicholson et al. | Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types | 2013 |
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Dr Maria Lastowska Hani Al-Afghani Haya AL-Balool Harsh SHETH Dr Jonathan Coxhead et al. | Identification of a neuronal transcription factor network involved in medulloblastoma development | 2013 |
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Dr Matthew Allen Dr Daniel Williamson Professor Steven Clifford
| Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells | 2013 |
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Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Professor Simon Bailey Professor Steven Clifford et al. | Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma | 2013 |
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Dr Sarra Ryan Dr Ed Schwalbe Mike Cole Yuan Lu Dr Meryl Lusher et al. | MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma | 2012 |
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Dr Stephen Crosier Sarah Nicholson Dr Nicholas Bown Professor Steven Clifford
| A National Feasibility Study of Real-Time Central Pathology Review and Molecular Diagnostics for Medulloblastoma | 2012 |
|
Dr Daniel Williamson Professor Steven Clifford
| A significant proportion of medulloblastoma do not sub-group robustly: Identification of a molecular NOS (not otherwise specified) subgroup | 2012 |
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Dr Daniel Williamson Professor Steven Clifford
| Biological and clinical heterogeneity of MYCN-amplified medulloblastoma | 2012 |
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Professor Steven Clifford
| Cancer Genetics: Evolution after tumour spread | 2012 |
|
Professor Steven Clifford
| Delineating the genomic differences between primary and recurrent medulloblastoma | 2012 |
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Dr Daniel Williamson Professor Steven Clifford
| Dissecting the genomic complexity underlying medulloblastoma | 2012 |
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Dr Ed Schwalbe Dr Janet Lindsey Dr Daniel Williamson Kieran O'Toole Dr Meryl Lusher et al. | Epigenetic sub-classification and risk-stratification of medulloblastoma using DNA methylomics | 2012 |
|
Professor Steven Clifford
| Hyperfractionated Versus Conventional Radiotherapy Followed by Chemotherapy in Standard-Risk Medulloblastoma: Results From the Randomized Multicenter HIT-SIOP PNET 4 Trial | 2012 |
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Dr James Hayden Dr Christopher Jones Professor Steven Clifford
| Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis | 2012 |
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Professor Steven Clifford Professor David Ellison Dr Richard Gilbertson
| Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas | 2012 |
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Professor Steven Clifford Professor David Ellison Dr Richard Gilbertson
| Molecular subgroups of medulloblastoma: the current consensus | 2012 |
|
Professor Steven Clifford
| Polo-Like Kinase 1 (PLK1) Inhibition Reduces Cell Proliferation and Induces Apoptosis in Childhood Acute Lymphoblastic Leukemia | 2012 |
|
Professor Steven Clifford
| Prognostic and therapeutic role of TP53 mutations in medulloblastoma subgroups; therapeutic role of lithium in abrogation of TP53 mutation associated radiation resistance | 2012 |
|
Dr Janet Lindsey Professor Simon Bailey Professor Steven Clifford
| Subgroup-specific structural variation across 1,000 medulloblastoma genomes | 2012 |
|
Dr Ed Schwalbe Professor Steven Clifford
| Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death | 2012 |
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Dr Jonathan Fisher Lisa Price Dr Juliet Hale Professor Steven Clifford Professor Simon Bailey et al. | The importance of biopsy following radiological diagnosis of relapsed medulloblastoma | 2012 |
|
Sarah Nicholson Dr Nicholas Bown Professor Steven Clifford
| A feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma in the United Kingdom | 2011 |
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Professor David Ellison Dr Hisham Megahed Dr Meryl Lusher Dr Sarra Ryan Professor Simon Bailey et al. | Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables | 2011 |
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Dr Ed Schwalbe Professor Steven Clifford
| Genome-Wide Analysis of Alternative Splicing in Medulloblastoma Identifies Splicing Patterns Characteristic of Normal Cerebellar Development | 2011 |
|
Dr Vikki Rand Professor Steven Clifford Dr James Hayden
| Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma | 2011 |
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Professor Steven Clifford
| Medulloblastoma Comprises Four Distinct Molecular Variants | 2011 |
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Professor David Ellison Sarah Nicholson Professor Simon Bailey Professor Steven Clifford Dr Richard Gilbertson et al. | Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups | 2011 |
|
Dr Ed Schwalbe Professor Steven Clifford
| Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance | 2011 |
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Professor Steven Clifford
| Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct | 2011 |
|
Dr Ed Schwalbe Dr Janet Lindsey Debbie Straughton Mike Cole Dr Hisham Megahed et al. | Rapid Diagnosis of Medulloblastoma Molecular Subgroups | 2011 |
|
Dr Meryl Lusher Dr Janet Lindsey Professor Steven Clifford
| RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines | 2011 |
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Dr Janet Lindsey Dr Rebecca Hill Dr Hisham Megahed Dr Meryl Lusher Dr Ed Schwalbe et al. | TP53 Mutations in Favorable-Risk Wnt/Wingless-Subtype Medulloblastomas | 2011 |
|
Rachel Daniel Dr Agata Rozanska Dr Evan Mulligan Dr Yvette Drew Huw Thomas et al. | Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699 | 2010 |
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Dr Ed Schwalbe Professor Steven Clifford Dr Richard Gilbertson
| Characteristic Genomic Imbalances in Paediatric Ependyoma; The Importance of Chromosome 1Q Gain | 2010 |
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Dr Hisham Megahed Dr Sarra Ryan Dr Meryl Lusher Sarah Nicholson Professor Simon Bailey et al. | Clinical, Pathological, and Molecular Variables Define Risk-Stratification Groups in Childhood Medulloblastoma | 2010 |
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Professor David Ellison Dr Hisham Megahed Dr Sarra Ryan Dr Meryl Lusher Sarah Nicholson et al. | Clinical, pathological, and molecular variables define risk-stratification groups in childhood medulloblastoma | 2010 |
|
Dr Ed Schwalbe Dr Janet Lindsey Dr Meryl Lusher Kieran O'Toole Sarah Nicholson et al. | DNA methylomics identifies clinically significant epigenetic subgroups of medulloblastoma | 2010 |
|
Sarah Nicholson Dr Nicholas Bown Professor Steven Clifford
| Establishment of real-time centralised pathology review (CPR) and molecular diagnostics for medulloblastoma in the United Kingdom | 2010 |
|
Dr James Hayden Dr Matthew Allen Dr Sarra Ryan Sarah Nicholson Dr Ed Schwalbe et al. | Molecular Mechanisms in Supratentorial CNS-PNET development | 2010 |
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Professor Steven Clifford Dr Sarra Ryan Mike Cole Dr Meryl Lusher Kieran O'Toole et al. | MYC gene family amplification and expression in childhood medulloblastoma: Biological significance and utility for high-risk disease stratification | 2010 |
|
Dr Britta Vormoor Professor Nicola Curtin Professor Steven Clifford
| Sensitisation of paediatric solid tumours to DNA-damaging chemotherapy by inhibition of DNA-dependent protein kinase (PRKDC) | 2010 |
|
Professor Steven Clifford
| Stratification of children and adolescents with medulloblastoma by histological and biological parameters in SIOP-Europe PNET clinical trials | 2010 |
|
Dr Janet Lindsey Professor Steven Clifford Professor David Ellison Dr Richard Gilbertson
| Subtypes of medulloblastoma have distinct developmental origins | 2010 |
|
Dr Agata Rozanska Dr Evan Mulligan Huw Thomas Deborah Castelbuono Professor Deborah Tweddle et al. | [abstract] Central nervous system (CNS) penetration, poly-ADP ribose polymerase (PARP) inhibition and enhancement of temozolomide activity against childhood medulloblastoma by AG-014699 | 2009 |
|
Professor Steven Clifford Dr Nicholas Bown
| A feasibility study of real-time biological characterisation of medulloblastoma in the United Kingdom | 2009 |
|
Dr Sarra Ryan Professor David Elliott Professor David Ellison Professor Simon Bailey Professor Steven Clifford et al. | Amplification and overexpression of Hsa-miR-3ob, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma | 2009 |
|
Professor Steven Clifford Kieran O'Toole Professor David Ellison
| Chromosome 1q gain is not associated with a poor outcome in childhood medulloblastoma: requirements for the validation of potential prognostic biomarkers | 2009 |
|
Dr James Hayden Professor David Ellison Professor Simon Bailey Professor Steven Clifford
| Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children | 2009 |
|
Professor Steven Clifford Professor David Ellison Kieran O'Toole
| Improved Stratification of Standard Risk Medulloblastoma Patients by Clinical and Biological Prognostic Factors | 2009 |
|
Dr Agata Rozanska Huw Thomas Dr Evan Mulligan Dr Yvette Drew Deborah Castelbuono et al. | Inhibition of Poly (ADP-Ribose) Polymerase-1 Enhances Temozolomide and Topotecan Activity against Childhood Neuroblastoma | 2009 |
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Dr Janet Lindsey Professor Steven Clifford
| Methylation-Controlled J Protein | 2009 |
|
Professor Steven Clifford Professor David Ellison
| Novel mechanisms of gene disruption at the medulloblastoma isodicentric 17p11 breakpoint | 2009 |
|
Professor Steven Clifford
| The potential impact of tumour biology on improved clinical practice for medulloblastoma: progress towards biologically driven clinical trials | 2009 |
|
Jennifer Anderton Dr Janet Lindsey Dr Meryl Lusher Dr Richard Gilbertson Professor Simon Bailey et al. | Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2 | 2008 |
|
Professor David Ellison Professor Steven Clifford
| Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features | 2008 |
|
Professor Steven Clifford
| KidsCancerKinome: a EU-FP6 project for preclinical kinase inhibitor evaluation as a tool to prioritize compounds for paediatric development | 2008 |
|
Professor Steven Clifford
| Medulloblastoma: new insights into biology and treatment | 2008 |
|
Professor Steven Clifford Dr Meryl Lusher Dr Janet Lindsey Dr Jackie Langdon Dr Richard Gilbertson et al. | Wnt-pathway medulloblastomas | 2008 |
|
Professor David Ellison Dr Janet Lindsey Dr Meryl Lusher Professor Steven Clifford
| Beta-catenin status predicts favorable prognosis in childhood medulloblastoma | 2007 |
|
Professor Steven Clifford Yuan Lu Dr Debbie Scott Professor David Ellison
| Chromosome 8 contains multiple independent loci involved in medulloblastoma development | 2007 |
|
Dr Janet Lindsey Dr Meryl Lusher Jennifer Anderton Dr Richard Gilbertson Professor David Ellison et al. | Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma | 2007 |
|
Professor Steven Clifford
| Expression of drugable targets in pediatric malignancies: Innovative therapies for children with cancer | 2007 |
|
Professor Steven Clifford Professor David Ellison
| Identification of novel mechanisms for gene disruption at the medulloblastoma isochromosome breakpoint locus | 2007 |
|
Charles McManamy Dr Jane Pears Professor Steven Clifford Professor David Ellison
| Nodule formation and desmoplasia in medulloblastomas - Defining the nodular/desmoplastic variant and its biological behavior | 2007 |
|
Professor Steven Clifford
| Paediatric brain tumours: exploiting genomics to improve therapies | 2007 |
|
Professor Steven Clifford Rachel Daniel Dr Agata Rozanska Huw Thomas Professor Alan Boddy et al. | Preclinical evaluation of the POLY-ADP ribose polymerase 1 (PARP-1) inhibitor AG014699 in combination with topotecan and temozolomide for the treatment of medulloblastoma and neuroblastoma | 2007 |
|
Olabisi Onilude Dr Meryl Lusher Dr Janet Lindsey Professor Andrew Pearson Professor David Ellison et al. | APC and CTNNB1 mutations are rare in sporadic ependymomas | 2006 |
|
Dr Jackie Langdon Dr Jayne Lamont Dr Debbie Scott Dr Nicholas Bown Professor David Ellison et al. | Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma | 2006 |
|
Dr Janet Lindsey Dr Meryl Lusher Dr Gordon Strathdee Robert Brown Dr Richard Gilbertson et al. | Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours | 2006 |
|
Dr Janet Lindsey Dr Meryl Lusher Dr Gordon Strathdee Dr Richard Gilbertson Professor Simon Bailey et al. | Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours | 2006 |
|
Dr Poonam Dharmaraj Dr Stephen Ball Dr HC Johnstone Professor Simon Bailey Professor Steven Clifford et al. | Hypercalcaemia in relapsed medulloblastoma 8 years post-diagnosis; evidence to support PTHrP production by medulloblastoma cells | 2006 |
|
Dr Debbie Scott Debbie Straughton Mike Cole Professor Simon Bailey Professor David Ellison et al. | Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma | 2006 |
|
Dr Richard Gilbertson Dr Jackie Langdon Roberto Hernan Professor Steven Clifford
| Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma | 2006 |
|
Professor Steven Clifford Dr Meryl Lusher Dr Janet Lindsey Dr Jackie Langdon Dr Richard Gilbertson et al. | Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis | 2006 |
|
Professor David Ellison Olabisi Onilude Dr Janet Lindsey Dr Meryl Lusher Professor Andrew Pearson et al. | β-catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee | 2005 |
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Dr Jayne Lamont Professor Deborah Tweddle Professor Andrew Pearson Professor Steven Clifford Professor David Ellison et al. | A 7-year-old boy with midline cerebellar mass | 2005 |
|
Dr Janet Lindsey Jennifer Anderton Dr Meryl Lusher Professor Steven Clifford
| Epigenetic events in medulloblastoma development | 2005 |
|
David Hamilton Dr Meryl Lusher Dr Janet Lindsey Professor David Ellison Professor Steven Clifford et al. | Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma | 2005 |
|
Dr Kevin Jones Professor Steven Clifford
| Preclinical target analyisis in pediatric malignancies for selecting targeted compounds: Innovative therapies for children with cancer. | 2005 |
|
Dr Christopher Calabrese Professor Steven Clifford Dr Richard Gilbertson
| The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation | 2005 |
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Dr Christopher Calabrese Professor Steven Clifford Dr Richard Gilbertson
| The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation | 2005 |
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Professor David Ellison Professor Andrew Pearson Professor Steven Clifford Dr Jayne Lamont Charles McManamy et al. | Combined histopathological and molecular cytogenetic stratification defines a high-risk subset of patients with medulloblastoma - A United Kingdom Children's Cancer Group Study | 2004 |
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Dr Jayne Lamont Charles McManamy Professor Andrew Pearson Professor Steven Clifford Professor David Ellison et al. | Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients | 2004 |
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Professor Steven Clifford Dr Janet Lindsey Dr Meryl Lusher Dr Richard Gilbertson Professor Andrew Pearson et al. | Identification of tumour suppressor genes in childhood medulloblastoma by promoter hypermethylation profiling | 2004 |
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Dr Janet Lindsey Dr Meryl Lusher Jennifer Anderton Professor Simon Bailey Dr Richard Gilbertson et al. | Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling | 2004 |
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Professor David Ellison Charles McManamy Professor Andrew Pearson Professor Steven Clifford
| The clinical utility of stratifying medulloblastomas (MBs) by a combination of detailed histopathologic evaluation and molecular cytogenetic analysis | 2004 |
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Professor Steven Clifford
| The molecular genetics and pathology of renal cell carcinoma | 2004 |
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Dr Adrian Frank Roberto Hernan Dr Janet Lindsey Dr Meryl Lusher Professor Steven Clifford et al. | The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma | 2004 |
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James Cooke Professor Steven Clifford
| Identification of pVHL-interacting proteins and their role in pheochromocytoma development | 2003 |
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Dr Janet Lindsey Dr Meryl Lusher Professor Andrew Pearson Professor David Ellison Professor Steven Clifford et al. | Identification of tumour suppressor genes in childhood medulloblastoma by promoter hypermethylation profiling | 2003 |
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Dr Debbie Scott Dr Janet Lindsey Dr Meryl Lusher Professor Andrew Pearson Professor David Ellison et al. | Identification of tumour suppressor loci on chromosome 10q in medulloblastoma | 2003 |
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Dr Jackie Langdon Roberto Hernan Dr Richard Gilbertson Professor Steven Clifford
| Molecular analysis of the PDGFR alpha-RAS/MAPK pathway in childhood medulloblastoma | 2003 |
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Dr Jayne Lamont Charles McManamy Professor Andrew Pearson Professor Steven Clifford Professor David Ellison et al. | Molecular cytogenetic analysis of a cohort of medulloblastomas | 2003 |
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Charles McManamy Dr Jayne Lamont Mike Cole Professor Andrew Pearson Professor Steven Clifford et al. | Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas | 2003 |
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Dr Richard Gilbertson Professor Steven Clifford
| PDGFRB is overexpressed in metastatic medulloblastoma | 2003 |
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Professor David Ellison Professor Steven Clifford Dr Richard Gilbertson
| What's new in neuro-oncology? Recent advances in medulloblastoma | 2003 |
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Dr Meryl Lusher Dr Janet Lindsey Professor Andrew Pearson Professor David Ellison Professor Steven Clifford et al. | Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development | 2002 |
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Professor Steven Clifford
| Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease | 2002 |
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Professor Steven Clifford
| Mucilages and polysaccharides in Ziziphus species (Rhamnaceae): localization, composition and physiological roles during drought-stress | 2002 |
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Professor Steven Clifford
| Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas | 2001 |
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Professor Steven Clifford
| Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas | 2001 |
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Professor Steven Clifford
| Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease | 2001 |
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Professor Steven Clifford
| Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease | 2001 |
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Professor Steven Clifford
| The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma | 2001 |
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Professor Steven Clifford
| The pVHL-associated SCF ubiquitin ligase complex: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma | 2001 |
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Professor Steven Clifford
| Von Hippel-Lindau disease: clinical and molecular perspectives | 2001 |
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Professor Steven Clifford
| Comparative sequence analysis of the VHL tumor suppressor gene | 2000 |
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Professor Steven Clifford
| Familial clear cell renal cell carcinoma (FCRC): clinical features and mutation analysis of the VHL, MET, and CUL2 candidate genes | 2000 |
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Professor Steven Clifford
| Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein | 2000 |
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Professor Steven Clifford
| Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein | 2000 |
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Professor Steven Clifford
| Differences in allelic distribution of two polymorphisms in the VHL-associated gene CUL2 in pheochromocytoma patients without somatic CUL2 mutations | 1999 |
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Professor Steven Clifford
| Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development | 1999 |
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Professor Steven Clifford
| Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development | 1999 |
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Professor Steven Clifford
| The molecular genetics of renal cell carcinoma | 1999 |
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Professor Steven Clifford
| The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | 1999 |
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Dr Richard Gilbertson Professor Steven Clifford Dr Christopher Wright Emeritus Professor Robert Perry Professor Andrew Pearson et al. | Expression of the ErbB-neuregulin signaling network during human cerebellar development: Implications for the biology of medulloblastoma | 1998 |
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Professor Steven Clifford
| Hepatocyte growth factor-stimulated renal tubular mitogenesis: effects on expression of c-myc, c-fos, c-met, VEGF and the VHL tumour-suppressor and related genes | 1998 |
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Professor Steven Clifford
| Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis | 1998 |
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Professor Steven Clifford Professor David Neal Professor John Lunec
| Alterations in expression of the multidrug resistance-associated protein (MRP) gene in high-grade transitional cell carcinoma of the bladder | 1996 |
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Professor Steven Clifford Professor David Neal Professor John Lunec
| High level expression of the multidrug resistance (MDR1) gene in the normal bladder urothelium: A potential involvement in protection against carcinogens? | 1996 |
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Professor Steven Clifford David Thomas Professor David Neal Professor John Lunec
| Increased MDR1 gene transcript levels in high-grade carcinoma of the bladder determined by quantitative PCR-based assay | 1994 |
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