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Lookup NU author(s): Dr Joao Passos,
Professor Thomas von Zglinicki,
Dr Gabriele Saretzki
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The mitochondrial theory of aging remains to date one of the most popular theories of aging. One major model of aging is replicative senescence, where the irreversible loss of division potential of somatic cells occurs after a more or less constant number of cell divisions. Few data are available concerning the role of mitochondria in this model. Here, we review evidence supporting the involvement of mitochondria in replicative senescence and a possible link to telomere biology. Moreover, we suggest that this process might be more complex than originally formulated, because variations in nuclear gene expression involved in mitochondrion nucleus cross-talk are observed in both senescence and immortalization. © Mary Ann Liebert, Inc.
Author(s): Passos JF, Von Zglinicki T, Saretzki G
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: 2nd Conference on Strategies for Engineered Negligible Senescence (SENS)
Year of Conference: 2006
Publisher: Rejuvenation Research, Mary Ann Liebert, Inc. Publishers
PubMed id: 16608398
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