Browse by author
Lookup NU author(s): Dr Claudia Racca,
Professor Mark Cunningham,
Professor Miles Whittington,
Dr Fiona LeBeau
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Alzheimer's disease is associated with a dramatic decline in cognitive performance including hippocampal-dependent memory. We have investigated one feature of hippocampal activity related to memory, the γ (30-80 Hz)-frequency rhythm. Hippocampal slices from mice overexpressing the human amyloid precursor protein (APP)SWE mutation (TAS10) were compared at 8 and 16 months of age with wild-type littermates. In slices obtained from TAS10 mice aged 8 months the γ-frequency activity evoked with bath application of 200 nm kainate was significantly (P < 0.05; n = 8 slices, five animals) impaired (area power, 5956 ± 2487 μV2) compared to slices from wild-type animals (area power, 18 256 ± 7880 μV2). At 16 months of age there was no longer a significant difference (P > 0.05; n = 11 slices from five animals) between slices from TAS10 and wild-type control mice as the wild-type mice now exhibited a marked age-dependent reduction in γ-frequency activity (TAS10 area power, 5751 ± 1573 μV 2; wild-type area power = 5379 ± 1454 μV2). Although no dense-core plaques were evident at 8 months there was detectable amyloid labelling in the TAS10 mice which might account for the deficits in γ activity observed at this age. Dense plaques were clearly evident in the TAS10, but not wild-type, mice at 16 months of age but no further reductions in γ-frequency activity were seen in the TAS10 mice. These data suggest that deficits in network function in Alzheimer's disease occur early and are not directly correlated to amyloid load. © The Authors (2007).
Author(s): Driver JE, Racca C, Cunningham MO, Towers SK, Davies CH, Whittington MA, Le Beau FEN
Publication type: Article
Publication status: Published
Journal: European Journal of Neuroscience
ISSN (print): 0953-816X
ISSN (electronic): 1460-9568
Publisher: Wiley-Blackwell Publishing Ltd.
PubMed id: 17767505
Altmetrics provided by Altmetric