Toggle Main Menu Toggle Search

Open Access padlockePrints

A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis

Lookup NU author(s): Dr Martin Prince, Professor Margaret Bassendine, Dr Mark Hudson, Emeritus Professor Oliver James, Professor David Jones, Dr Christopher Record, Professor Chris Day


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background/Aims: Oxidative stress is putatively involved in the pathogenesis of alcohol-induced liver injury. This trial was devised to determine whether antioxidant therapy, alone or as an adjunct to corticosteroids, improved survival in patients with acute alcoholic hepatitis. Methods: Patients with a severe alcoholic hepatitis were stratified by sex and steroid use, and then randomized. The active group received N-acetylcysteine for one week, and vitamins A-E, biotin, selenium, zinc, manganese, copper, magnesium, folic acid and Coenzyme Q daily for 6 months. The trial was double blinded and placebo controlled. The primary end-point was mortality within 6 months. Results: Thirty-six (20 male, 16 female; mean discriminant function (DF) 86.6) received active drug, and 34 (18 male, 16 female; mean DF 76.4) received placebo. 180-day survival was not significantly different between patients receiving drug and placebo (52.8% vs. 55.8%, p = 0.699). This was not affected by stratification for steroid use or sex. The only predictors of survival in multivariate analysis were initial bilirubin (p = 0.017), white cell count (p = 0.016) and age (p = 0.037). Treatment allocation did not affect survival in multivariate analysis (p = 0.830). Conclusions: Antioxidant therapy, alone or in combination with corticosteroids, does not improve 6-month survival in severe alcoholic hepatitis. © 2007 European Association for the Study of the Liver.

Publication metadata

Author(s): Stewart S, Prince M, Bassendine M, Hudson M, James O, Jones D, Record C, Day CP

Publication type: Article

Publication status: Published

Journal: Journal of Hepatology

Year: 2007

Volume: 47

Issue: 2

Pages: 277-283

Print publication date: 01/08/2007

ISSN (print): 0168-8278

ISSN (electronic): 1600-0641

Publisher: Elsevier BV


DOI: 10.1016/j.jhep.2007.03.027

PubMed id: 17532088


Altmetrics provided by Altmetric