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A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: Inhibition of NF-κB?

Lookup NU author(s): Dr David Cowie, Professor Derek Mann, Professor Matthew Wright



The liver is susceptible to chronic damage through exposure to a variety of toxins (e.g. alcohol) and viruses (e.g. hepatitis C). Obesity, autoimmune diseases (e.g. autoimmune hepatitis) and a variety of genetic diseases (e.g. Wilson's disease) also lead to chronic liver damage. This damage results in scarring fibrogenesis, structural disruption and functional impairment of the organ. Recent work suggests that there is cross-talk between the PXR and NF-κB pathways. This cross-talk may explain the observation that PXR activators inhibit liver fibrosis in in vitro and in vivo animal models of the disease. This reveiw will focus on the two transcription factors and their potential interaction. © 2007 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Axon A, Cowie DE, Mann DA, Wright MC

Publication type: Review

Publication status: Published

Journal: Toxicology

Year: 2008

Volume: 246

Issue: 1

Pages: 40-44

ISSN (print): 0300-483X

ISSN (electronic):


DOI: 10.1016/j.tox.2007.12.008

PubMed id: 18194834